摘要
目的:探讨不同药物方案治疗幽门螺杆菌阳性消化性溃疡的临床疗效。方法:选取我院收治的幽门螺杆菌阳性消化性溃疡患者90例,选取时间为2023年1月至2023年7月,根据信封法分为试验组和参照组,参照组采用奥美拉唑治疗,试验组在此基础上采用双歧杆菌四联活菌片联合治疗,比较两组患者临床疗效,观察两组患者Hp清除率、Hp清除时间和溃疡愈合时间,并比较两组患者治疗前后胃肠激素和炎性因子水平,观察两组患者不良反应发生情况。结果:试验组治疗总有效率(95.56%)高于参照组(80.00%)(χ^(2)=6.535,P=0.011)。与参照组(77.78%)比较,试验组患者Hp清除率(93.33%)高于参照组,Hp清除时间和溃疡愈合时间更短(P<0.05)。治疗后试验组患者MTL和GAS水平更低,CGRP水平更高(P<0.05)。治疗后试验组患者TNF-α、IL-6和CRP水平更低(P<0.05)。两组不良反应发生率(13.33%vs 11.11%)无明显差异(χ^(2)=0.104,P=0.747)。结论:奥美拉唑基础上采用双歧杆菌四联活菌片联合治疗幽门螺杆菌阳性消化性溃疡的临床疗效显著,可提高Hp清除率,改善胃肠功能,减轻炎症反应,安全性高。
Objective:Combined with clinical experience,the clinical efficacy of compound bismuth potassium citrate metronidazole capsule combined with omeprazole in the treatment of Helicobacter pylori positive peptic ulcer was discussed.Methods:A total of 90 patients with helicobacter pylori positive peptic ulcer admitted to our hospital from January 2023 to July 2023 were selected and divided into experimental group and reference group according to envelope method.The reference group was treated with omeprazole,and the experimental group was treated with bifidobacterium quadruplex viable tablet on this basis.The clinical efficacy of the two groups was compared.The Hp clearance rate,Hp clearance time and ulcer healing time of the two groups were observed,and the levels of gastrointestinal hormones and inflammatory factors before and after treatment were compared between the two groups,and the occurrence of adverse reactions was observed.Results:The total effective rate of experimental group(95.56%)was higher than that of control group(80.00%)(χ^(2)=6.535,P=0.011).Compared with the reference group(77.78%),the Hp clearance rate of experimental group(93.33%)was higher than that of the reference group,and the Hp clearance time and ulcer healing time were shorter(P<0.05).Compared with the reference group,after treatment,the levels of MTL and GAS in experimental group were lower,and the levels of CGRP were higher(P<0.05).Compared with the control group,the levels of TNF-α,IL-6 and CRP in experimental group were lower after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(13.33%vs 11.11%)(χ^(2)=0.104,P=0.747).Conclusion:On the basis of omeprazole,bifidobacterium quadruplex viable tablet combined with treatment of Helicobacter pylori positive peptic ulcer has significant clinical efficacy,can increase Hp clearance,improve gastrointestinal function,reduce inflammation,and high safety.
作者
张毛
牛思
邵阿康
Zhang Mao;Niu Si;Shao A-kang(Department of Gastroenterology,Nanyang Central Hospital,Nanyang 473000,Henan,China)
