Two series of novel derivatives of imidazo[4,5-b]pyridine were synthesized. These compounds could be used as side chains of semisynthesised ketolide antibiotics. The side chains have free amine group which can attache...Two series of novel derivatives of imidazo[4,5-b]pyridine were synthesized. These compounds could be used as side chains of semisynthesised ketolide antibiotics. The side chains have free amine group which can attached to ketolide core. Macrolides with this kind of side chains will show obvious activities against erythromycin-resistant strains. The structure of the side chains was confirmed by ^1H, ^13C NMR, MS, HMBC spectra. 2007 Ping Sheng Lei. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
After type A acute aortic dissection(AAD)repair or modified Bentall procedure,uncontrollable bleeding from the anastomotic sites of the fragile dissected tissues or aortic root area is a critical situation to a cardia...After type A acute aortic dissection(AAD)repair or modified Bentall procedure,uncontrollable bleeding from the anastomotic sites of the fragile dissected tissues or aortic root area is a critical situation to a cardiac surgeon.For postoperative care,lots of blood transfusion with strict monitoring on the patient all night and subsequent reoperation for the bleeding control is usually needed.We managed to make contained local compression of upper half of the heart,from upper part of the right ventricle to just above the innominate vein,using bovine pericardium with closing both sides of transverse sinus in two cases of uncontrolled postoperative bleeding(bleeding from distal anastomotic site in type-A AAD and valve sitting site in modified Bentall procedure).Even though reoperations for the removal of packed gauges were done in both cases 2 days later,postoperative courses at intensive care unit were very smooth with little need for transfusion.This kind of contained local compression trial could be a useful strategy for dealing with the malignant uncontrollable bleeding from the fragile aortic tissue or root area after acute dissection or aortic root repair.展开更多
According to the observation in experiment of stability of the oil film, the assumption of velocity distribution for both the water flow and the oil film is introduced. On the basis of the assumption, Orr-Sommerfeld s...According to the observation in experiment of stability of the oil film, the assumption of velocity distribution for both the water flow and the oil film is introduced. On the basis of the assumption, Orr-Sommerfeld stability equation is applied to develop the method of determining the critical velocity of the oil film, and the criterion for stability of the oil film is obtained. Meanwhile, a formula describing the relation between the thickness of the oil film and the velocity of the water flow is also given and examined by the laboratory experiment.展开更多
The hormone defined serum free conditioned medium (SFCM) of human nasopharyngeal carcinoma epithelioid cell line (CNE1) was assayed by both the 3H-thymidine incorporation test and the soft agar test. It was found that...The hormone defined serum free conditioned medium (SFCM) of human nasopharyngeal carcinoma epithelioid cell line (CNE1) was assayed by both the 3H-thymidine incorporation test and the soft agar test. It was found that the SFCM stimulated the growth of long-term serum-free cultured CNE4 cells in ac-cordence with the fact that the growth rate of long-term serum-free cultured CNE1 cells was directly proportional to the plating density. Alternatively 5% SFCM inhibited the growth of short-term serum-free cultured CNE4 cells by 51% in which the indicator cell remained the responsiveness state of growing in the serum-supplemented medium to the effector of interest. Furthermore, SFCM resulted in the inhibition of anchorage-independent growth of CNE4 cells and A431 cells. Also in soft agar test. SFCM reduced the colony formation of NRK(?),9F cells in the presence of EGF or EGF plus TGF-β. These finding suggested that CNE4 secreted autocrine growth stimulating factor(s) and growth inhibiting factor(s) in the serum-free medium, the latter strongly reverse malignant phenotypes of CNE4 and A431 cells in serum-supplemented surrounding.展开更多
The strength and stiffness contribution of infill masonry is generally ignored in the design, due to the uncertainty in the strength properties of masonry, separation of infill from frame, low tensile strength, brittl...The strength and stiffness contribution of infill masonry is generally ignored in the design, due to the uncertainty in the strength properties of masonry, separation of infill from frame, low tensile strength, brittle characteristics of masonry walls, less out of plane strength and stiffness, etc.. They are considered as nonstructural elements which is reasonable for the frames under gravity loads but it is not true for the frames under seismic loads. Contained masonry as infill in RC （reinforced concrete） frames provides better contact at the interface and a higher out of plane strength and stiffness. Considering the seismic action on the frames which are likely to be subjected to in-plane as well as out of plane shaking, a research work has been carried out by the authors to investigate the seismic performance of RC frames with and without contained masonry infill panels using FE （finite element） computer program （ANSYS-Ver. l 1） and experimentally using the tri-axial shake table to evaluate the methods proposed in IS-1893-2002 to calculate the fundamental natural frequency. The RC frames were designed and detailed as per IS （Indian Standard） specifications such as IS 456-2000, IS 1893-2002 and IS 13920-1993. Based on the experimental and analytical investigations, the contained masonry infill panels significantly affect the seismic load resisting characteristics of the RC frames. The IS 1893-2002 formulation does not predict the values and hence the recommendation needs to be validated with experimental results.展开更多
The anti-corruption battle must go deeper,President Xi Jinping said on January 6,calling for strict governance of the Communist Party of China(CPC)systematically,creatively and effectively.Xi,also General Secretary of...The anti-corruption battle must go deeper,President Xi Jinping said on January 6,calling for strict governance of the Communist Party of China(CPC)systematically,creatively and effectively.Xi,also General Secretary of the CPC Central Committee and Chairman of the Central Military Commission。展开更多
Using the 3-D sono-elasticity method and the simplified nonstructural mass method,the different dynamic modeling methods of the added water for a single-hull structure are first analyzed in this study.Then,the complet...Using the 3-D sono-elasticity method and the simplified nonstructural mass method,the different dynamic modeling methods of the added water for a single-hull structure are first analyzed in this study.Then,the complete internal flow field method and the simplified nonstructural mass method of the contained water between the double hulls of a double-hull structure are investigated.Finally,based on the calculation and analysis under multiple conditions,a reasonable and simplified dynamic modeling method of added water and contained water is obtained.It is indicated that the mass of added water for a single-hull structure is closely related to the mass of total underwater displacement of the structure.With the increase in the analysis frequency,the mass of added water is characterized by first decreasing rapidly and then decreasing gradually and smoothly.The contained water between the double hulls is distributed to the pressure hull and the light shell based on the ratio of the impedances of the double hulls.The results can basically reflect the acoustic radiation characteristics of the double-hull structure.展开更多
As containerized environments become increasingly prevalent in cloud-native infrastructures,the need for effective monitoring and detection of malicious behaviors has become critical.Malicious containers pose signific...As containerized environments become increasingly prevalent in cloud-native infrastructures,the need for effective monitoring and detection of malicious behaviors has become critical.Malicious containers pose significant risks by exploiting shared host resources,enabling privilege escalation,or launching large-scale attacks such as cryptomining and botnet activities.Therefore,developing accurate and efficient detection mechanisms is essential for ensuring the security and stability of containerized systems.To this end,we propose a hybrid detection framework that leverages the extended Berkeley Packet Filter(eBPF)to monitor container activities directly within the Linux kernel.The framework simultaneously collects flow-based network metadata and host-based system-call traces,transforms them into machine-learning features,and applies multi-class classification models to distinguish malicious containers from benign ones.Using six malicious and four benign container scenarios,our evaluation shows that runtime detection is feasible with high accuracy:flow-based detection achieved 87.49%,while host-based detection using system-call sequences reached 98.39%.The performance difference is largely due to similar communication patterns exhibited by certain malware families which limit the discriminative power of flow-level features.Host-level monitoring,by contrast,exposes fine-grained behavioral characteristics,such as file-system access patterns,persistence mechanisms,and resource-management calls that do not appear in network metadata.Our results further demonstrate that both monitoring modality and preprocessing strategy directly influence model performance.More importantly,combining flow-based and host-based telemetry in a complementary hybrid approach resolves classification ambiguities that arise when relying on a single data source.These findings underscore the potential of eBPF-based hybrid analysis for achieving accurate,low-overhead,and behavior-aware runtime security in containerized environments,and they establish a practical foundation for developing adaptive and scalable detection mechanisms in modern cloud systems.展开更多
Container transportation is pivotal in global trade due to its efficiency,safety,and cost-effectiveness.However,structural defects—particularly in grapple slots—can result in cargo damage,financial loss,and elevated...Container transportation is pivotal in global trade due to its efficiency,safety,and cost-effectiveness.However,structural defects—particularly in grapple slots—can result in cargo damage,financial loss,and elevated safety risks,including container drops during lifting operations.Timely and accurate inspection before and after transit is therefore essential.Traditional inspection methods rely heavily on manual observation of internal and external surfaces,which are time-consuming,resource-intensive,and prone to subjective errors.Container roofs pose additional challenges due to limited visibility,while grapple slots are especially vulnerable to wear from frequent use.This study proposes a two-stage automated detection framework targeting defects in container roof grapple slots.In the first stage,YOLOv7 is employed to localize grapple slot regions with high precision.In the second stage,ResNet50 classifies the extracted slots as either intact or defective.The results from both stages are integrated into a human-machine interface for real-time visualization and user verification.Experimental evaluations demonstrate that YOLOv7 achieves a 99%detection rate at 100 frames per second(FPS),while ResNet50 attains 87%classification accuracy at 34 FPS.Compared to some state of the arts,the proposed system offers significant speed,reliability,and usability improvements,enabling efficient defect identification and visual reconfirmation via the interface.展开更多
Recent advancements in Zn-halogen batteries have focused on enhancing the adsorptive or catalytic capability of host materials and stabilizing complex intermediates with electrolyte additives,while the halogen-ion ele...Recent advancements in Zn-halogen batteries have focused on enhancing the adsorptive or catalytic capability of host materials and stabilizing complex intermediates with electrolyte additives,while the halogen-ion electrolyte modifications exhibit strong potential for integrated interfacial regulation.Herein,we design an electrically insulating rigid electrolyte container to immobilize a liquid halogen-ion electrolyte for separator-free Zn-halogen batteries with customizable electron transfer.Robust hydrogen bonding of hydroxyl groups in SiO_(2)with fluorinated moieties in PVDF-hfp regulates Zn^(2+)solvation and suppresses H_(2)O activity,while multi-channels formed by microcracks and interparticle gaps not only enhance mass transfer but also buffer interfacial electric field,jointly enabling a durable Zn plating/stripping.Effective confinement of intermediates also ensures the high reversibility across single-(I^(-)/I0),double-(I^(-)/I0/I^(-)),and triple-(I^(-)/I0/I^(-),Cl-/Cl0)electron transfer mechanisms at cathode,as evidenced by the double-electron transfer systems exhibiting a low capacity decay rate of 0.02‰over 4500 cycles at 10 mA cm^(-2)and a high areal capacity of 11.9 mAh cm^(-2)at 2 mA cm^(-2).This work presents a novel“container engineering”approach to halogen-ion electrolyte design and provides fundamental insights into the relationships between redox reversibility and reaction kinetics.展开更多
The bipartite containment control problem for heterogeneous nonlinear multi-agent systems(HNMASs)within multi-group networks under signed digraphs is investigated,where the first-order and second-order nonlinear dynam...The bipartite containment control problem for heterogeneous nonlinear multi-agent systems(HNMASs)within multi-group networks under signed digraphs is investigated,where the first-order and second-order nonlinear dynamic agents belong to distinct groups.Interactions are cooperative-antagonistic within each group and sign-in-degree balanced across the inter-groups.Firstly,a state feedback control protocol is designed to ensure that the trajectories of followers in diverse groups can converge to distinct convex hulls formed by their corresponding leaders,respectively.As an extension,the bipartite control problem with time-variant formation for the multi-agent system(MAS)is also considered,and a corresponding control protocol with formation compensation vectors is given.Finally,in view of Lyapunov stability theory and matrix inequality,the sufficient conditions for realizing the bipartite containment control are obtained,and several simulations are provided to verify the validity of the above methods.展开更多
Established in 2019,the Shandong Port Group(SPG)comprises four port groups(Qingdao Port,Rizhao Port,Yantai Port,and Bohaiwan Port)and 12 business segments.SPG connects 3,345 kilometers of coastline within Shandong Pro...Established in 2019,the Shandong Port Group(SPG)comprises four port groups(Qingdao Port,Rizhao Port,Yantai Port,and Bohaiwan Port)and 12 business segments.SPG connects 3,345 kilometers of coastline within Shandong Province.Its cargo throughput has consistently ranked first globally for many years,and its container volume growth ranks second globally,forming a port cluster covering the entire industrial chain.展开更多
Alzheimer’s disease(AD)is the most common form of dementia characterized pathologically by the deposition of amyloid plaques and hyperphosphorylated tau containing neurofibrillary tangles.The disease presents clinica...Alzheimer’s disease(AD)is the most common form of dementia characterized pathologically by the deposition of amyloid plaques and hyperphosphorylated tau containing neurofibrillary tangles.The disease presents clinically with progressive memory loss and disruption of cognitive function.Currently,there is no cure for AD;recent advances in the therapeutics aimed at clearing the amyloid protein from the brain have led to potential disease stabilization,however,this does not prevent eventual disease progression(Cummings et al.,2024).展开更多
Crystallized lithium fluoride(LiF)melts at 848℃ upon heating,and evaporates subsequently at a remarkably high temperature of 1673℃,characterizing its excellent thermally stability as one of the most representative m...Crystallized lithium fluoride(LiF)melts at 848℃ upon heating,and evaporates subsequently at a remarkably high temperature of 1673℃,characterizing its excellent thermally stability as one of the most representative metal halides.The marriage between Li F and rechargeable batteries dates back to early activities related to the electrochemical properties of lithium metal(Li°)negative electrodes,in which the nonaqueous electrolytes containing fluorinated salts were generally employed,e.g.,lithium tetrafluoroborate(LiBF_(4)),lithium hexafluoroarsenate(LiAsF_(6)),lithium trifluoromethanesulfonate(CF_(3)SO_(3)Li)[1].展开更多
Objectives:Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor(ER)α-positive breast cancer;however,resistance remains a significant clinical challenge.This study aims to investigate the mole...Objectives:Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor(ER)α-positive breast cancer;however,resistance remains a significant clinical challenge.This study aims to investigate the molecular mechanisms of tamoxifen resistance in ERα-positive breast cancer,with particular focus on the role of SET Domain Containing 1A(SETD1A)-driven forkhead box A2(FOXA2)as a key regulator of this resistance.Methods:FOXA2 expression and its regulation by SETD1A were assessed via(quantitative polymerase chain reaction),western blotting,transcriptome profiling,and chromatin immunoprecipitation analyses.The effects of FOXA2 on cell proliferation,migration,invasion,and cancer stem cell traits were evaluated using small interfering RNA(siRNA)-mediated silencing.Clinical relevance was examined by analyzing patient datasets and tumor tissue microarrays.Results:FOXA2 expression was significantly elevated in tamoxifen-resistant(TamR)and ERα-negative breast cancer cells compared to that in ERα-positive MCF-7 cells,regardless of tamoxifen treatment or ERαdepletion.Transcriptome and chromatin immunoprecipitation analyses revealed that SETD1A,a histone methyltransferase,directly regulated FOXA2 expression.Functionally,FOXA2 knockdown inhibited the proliferation,migration,invasion,and cancer stem cell properties of TamR cells while restoring tamoxifen sensitivity.High FOXA2 expression was correlated with poor survival and reduced responsiveness to tamoxifen in patients with ER-positive breast cancer.Conclusion:Our findings identified FOXA2 as a key mediator of tamoxifen resistance regulated by SETD1A and suggested that targeting the SETD1A-FOXA2 axis may offer a novel strategy for overcoming endocrine resistance in breast cancer.展开更多
Objective:Leucine-rich alpha-2 glycoprotein 1(Lrg1)could regulate diverse cells in cerebral ischemiareperfusion.Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways ...Objective:Leucine-rich alpha-2 glycoprotein 1(Lrg1)could regulate diverse cells in cerebral ischemiareperfusion.Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors.Method:The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing(scRNA-seq)data in middle cerebral artery occlusion reperfusion(MCAO/R).Monocle2 mapped endothelial differentiation paths.Gene set enrichment analysis(GSEA)analyzed endothelial subcluster variations.Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3(Zmiz1-Fzd3)promoter interaction.Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid.Polymerase chain reaction(PCR)and western blotting assessed MCAO/R or Zmiz1 overexpression effects on Fzd3-related mRNA and proteins.A retroviral vector carrying Zmiz1 was injected into the brains of mice to study its effect on Fzd3.Result:Lrg1−/−mice exhibited elevated cell adhesion proteins and decreased microvascular leakage after MCAO/R.CSOmap showed widened astrocyte spacing in thesemice.RSS revealed Zmiz1 overexpression inMCAO/R+Lrg1−/−mice.MCAO/R and pcDNA3-Zmiz1 transfection both enhanced luciferase activity with Fzd3,indicating Zmiz1 binding to Fzd3.Retroviral Zmiz1 injection or knockdown disrupted ischemic brain tight junctions,highlighting Zmiz1’s key role in blood-brain barrier protection,likely through Fzd3 pathway modulation.Conclusion:The findings indicate Lrg1 knockout induces endothelial differentiation by activating Zmiz1,which is crucial for maintaining blood-brain barrier function,possibly via modulating the Fzd3 pathway.展开更多
Objective:Triple-negative breast cancer(TNBC)is highly aggressive and lacks an effective targeted therapy.This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containin...Objective:Triple-negative breast cancer(TNBC)is highly aggressive and lacks an effective targeted therapy.This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2(ZMIZ2)and minichromosome maintenance complex component 3(MCM3)in TNBC progression.Methods:The relationship between ZMIZ2 expression and clinical characteristics of TNBC was investigated.In vitro and in vivo experiments were performed to investigate the role of ZMIZ2 dysregulation in TNBC cell malignant behaviors.The regulatory relationship between ZMIZ2 and MCM3 was also explored.Transcriptome sequencing was performed to elucidate possible mechanisms underlying the ZMIZ2/MCM3 axis in TNBC.Results:High ZMIZ2 expression levels were associated with the malignant degree of TNBC.ZMIZ2 overexpression promoted TNBC cell proliferation,migration,and invasion;inhibited apoptosis;and induced G1 phase cell cycle arrest,whereas knockdown of ZMIZ2 had the opposite effect.ZMIZ2 directly targeted and positively regulated MCM3 expression.MCM3 knockdown reversed the effect of ZMIZ2 overexpression on TNBC tumor growth both in vitro and in vivo.High MCM3 expression levels were linked to the degree of malignancy and poor prognosis in TNBC.The differentially expressed genes associated with the ZMIZ2/MCM3 axis were significantly enriched in multiple pathways,such as the mitogen-activated protein kinase(MAPK),mechanistic target of rapamycin(mTOR),Wnt,and Ras signaling pathways,as verified by The Cancer Genome Atlas data.Conclusions:ZMIZ2 and MCM3 were highly expressed in TNBC.ZMIZ2 promoted the development by positively regulating MCM3 expression.Key pathways,such as the Ras/MAPK,phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mTOR,and Wnt signaling pathways,may be key downstreammechanisms.展开更多
基金Finacial support of this research by the National Natural Science Foundation of China （No. 30572275） ；Natural Science Foundation of Beijing （No. 7062047） are gratefully acknowledged by the authors.
文摘Two series of novel derivatives of imidazo[4,5-b]pyridine were synthesized. These compounds could be used as side chains of semisynthesised ketolide antibiotics. The side chains have free amine group which can attached to ketolide core. Macrolides with this kind of side chains will show obvious activities against erythromycin-resistant strains. The structure of the side chains was confirmed by ^1H, ^13C NMR, MS, HMBC spectra. 2007 Ping Sheng Lei. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
文摘After type A acute aortic dissection(AAD)repair or modified Bentall procedure,uncontrollable bleeding from the anastomotic sites of the fragile dissected tissues or aortic root area is a critical situation to a cardiac surgeon.For postoperative care,lots of blood transfusion with strict monitoring on the patient all night and subsequent reoperation for the bleeding control is usually needed.We managed to make contained local compression of upper half of the heart,from upper part of the right ventricle to just above the innominate vein,using bovine pericardium with closing both sides of transverse sinus in two cases of uncontrolled postoperative bleeding(bleeding from distal anastomotic site in type-A AAD and valve sitting site in modified Bentall procedure).Even though reoperations for the removal of packed gauges were done in both cases 2 days later,postoperative courses at intensive care unit were very smooth with little need for transfusion.This kind of contained local compression trial could be a useful strategy for dealing with the malignant uncontrollable bleeding from the fragile aortic tissue or root area after acute dissection or aortic root repair.
文摘According to the observation in experiment of stability of the oil film, the assumption of velocity distribution for both the water flow and the oil film is introduced. On the basis of the assumption, Orr-Sommerfeld stability equation is applied to develop the method of determining the critical velocity of the oil film, and the criterion for stability of the oil film is obtained. Meanwhile, a formula describing the relation between the thickness of the oil film and the velocity of the water flow is also given and examined by the laboratory experiment.
文摘The hormone defined serum free conditioned medium (SFCM) of human nasopharyngeal carcinoma epithelioid cell line (CNE1) was assayed by both the 3H-thymidine incorporation test and the soft agar test. It was found that the SFCM stimulated the growth of long-term serum-free cultured CNE4 cells in ac-cordence with the fact that the growth rate of long-term serum-free cultured CNE1 cells was directly proportional to the plating density. Alternatively 5% SFCM inhibited the growth of short-term serum-free cultured CNE4 cells by 51% in which the indicator cell remained the responsiveness state of growing in the serum-supplemented medium to the effector of interest. Furthermore, SFCM resulted in the inhibition of anchorage-independent growth of CNE4 cells and A431 cells. Also in soft agar test. SFCM reduced the colony formation of NRK(?),9F cells in the presence of EGF or EGF plus TGF-β. These finding suggested that CNE4 secreted autocrine growth stimulating factor(s) and growth inhibiting factor(s) in the serum-free medium, the latter strongly reverse malignant phenotypes of CNE4 and A431 cells in serum-supplemented surrounding.
文摘The strength and stiffness contribution of infill masonry is generally ignored in the design, due to the uncertainty in the strength properties of masonry, separation of infill from frame, low tensile strength, brittle characteristics of masonry walls, less out of plane strength and stiffness, etc.. They are considered as nonstructural elements which is reasonable for the frames under gravity loads but it is not true for the frames under seismic loads. Contained masonry as infill in RC （reinforced concrete） frames provides better contact at the interface and a higher out of plane strength and stiffness. Considering the seismic action on the frames which are likely to be subjected to in-plane as well as out of plane shaking, a research work has been carried out by the authors to investigate the seismic performance of RC frames with and without contained masonry infill panels using FE （finite element） computer program （ANSYS-Ver. l 1） and experimentally using the tri-axial shake table to evaluate the methods proposed in IS-1893-2002 to calculate the fundamental natural frequency. The RC frames were designed and detailed as per IS （Indian Standard） specifications such as IS 456-2000, IS 1893-2002 and IS 13920-1993. Based on the experimental and analytical investigations, the contained masonry infill panels significantly affect the seismic load resisting characteristics of the RC frames. The IS 1893-2002 formulation does not predict the values and hence the recommendation needs to be validated with experimental results.
文摘The anti-corruption battle must go deeper,President Xi Jinping said on January 6,calling for strict governance of the Communist Party of China(CPC)systematically,creatively and effectively.Xi,also General Secretary of the CPC Central Committee and Chairman of the Central Military Commission。
基金supported by the National Natural Science Foundation of China(Grant No.51909246)supported by the Nature Science Foundation of Jiangsu Province of China(Grant No.BK20220044).
文摘Using the 3-D sono-elasticity method and the simplified nonstructural mass method,the different dynamic modeling methods of the added water for a single-hull structure are first analyzed in this study.Then,the complete internal flow field method and the simplified nonstructural mass method of the contained water between the double hulls of a double-hull structure are investigated.Finally,based on the calculation and analysis under multiple conditions,a reasonable and simplified dynamic modeling method of added water and contained water is obtained.It is indicated that the mass of added water for a single-hull structure is closely related to the mass of total underwater displacement of the structure.With the increase in the analysis frequency,the mass of added water is characterized by first decreasing rapidly and then decreasing gradually and smoothly.The contained water between the double hulls is distributed to the pressure hull and the light shell based on the ratio of the impedances of the double hulls.The results can basically reflect the acoustic radiation characteristics of the double-hull structure.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2024-00351898 and No.RS-2025-02263915)the MOTIE under Training Industrial Security Specialist forHigh-Tech Industry(RS-2024-00415520)supervised by theKorea Institute for Advancement of Technology(KIAT)+1 种基金the MSIT under the ICAN(ICT Challenge and Advanced Network of HRD)program(No.IITP-2022-RS-2022-00156310)supervised by the Institute of Information&Communication Technology Planning&Evaluation(IITP).
文摘As containerized environments become increasingly prevalent in cloud-native infrastructures,the need for effective monitoring and detection of malicious behaviors has become critical.Malicious containers pose significant risks by exploiting shared host resources,enabling privilege escalation,or launching large-scale attacks such as cryptomining and botnet activities.Therefore,developing accurate and efficient detection mechanisms is essential for ensuring the security and stability of containerized systems.To this end,we propose a hybrid detection framework that leverages the extended Berkeley Packet Filter(eBPF)to monitor container activities directly within the Linux kernel.The framework simultaneously collects flow-based network metadata and host-based system-call traces,transforms them into machine-learning features,and applies multi-class classification models to distinguish malicious containers from benign ones.Using six malicious and four benign container scenarios,our evaluation shows that runtime detection is feasible with high accuracy:flow-based detection achieved 87.49%,while host-based detection using system-call sequences reached 98.39%.The performance difference is largely due to similar communication patterns exhibited by certain malware families which limit the discriminative power of flow-level features.Host-level monitoring,by contrast,exposes fine-grained behavioral characteristics,such as file-system access patterns,persistence mechanisms,and resource-management calls that do not appear in network metadata.Our results further demonstrate that both monitoring modality and preprocessing strategy directly influence model performance.More importantly,combining flow-based and host-based telemetry in a complementary hybrid approach resolves classification ambiguities that arise when relying on a single data source.These findings underscore the potential of eBPF-based hybrid analysis for achieving accurate,low-overhead,and behavior-aware runtime security in containerized environments,and they establish a practical foundation for developing adaptive and scalable detection mechanisms in modern cloud systems.
文摘Container transportation is pivotal in global trade due to its efficiency,safety,and cost-effectiveness.However,structural defects—particularly in grapple slots—can result in cargo damage,financial loss,and elevated safety risks,including container drops during lifting operations.Timely and accurate inspection before and after transit is therefore essential.Traditional inspection methods rely heavily on manual observation of internal and external surfaces,which are time-consuming,resource-intensive,and prone to subjective errors.Container roofs pose additional challenges due to limited visibility,while grapple slots are especially vulnerable to wear from frequent use.This study proposes a two-stage automated detection framework targeting defects in container roof grapple slots.In the first stage,YOLOv7 is employed to localize grapple slot regions with high precision.In the second stage,ResNet50 classifies the extracted slots as either intact or defective.The results from both stages are integrated into a human-machine interface for real-time visualization and user verification.Experimental evaluations demonstrate that YOLOv7 achieves a 99%detection rate at 100 frames per second(FPS),while ResNet50 attains 87%classification accuracy at 34 FPS.Compared to some state of the arts,the proposed system offers significant speed,reliability,and usability improvements,enabling efficient defect identification and visual reconfirmation via the interface.
基金supported by the Science Fund for Distinguished Young Scholars of Hunan Province(2023JJ10060)the National Natural Science Foundation of China(22575269)Young Elite Scientists Sponsorship Program by CAST(2023QNRC001)。
文摘Recent advancements in Zn-halogen batteries have focused on enhancing the adsorptive or catalytic capability of host materials and stabilizing complex intermediates with electrolyte additives,while the halogen-ion electrolyte modifications exhibit strong potential for integrated interfacial regulation.Herein,we design an electrically insulating rigid electrolyte container to immobilize a liquid halogen-ion electrolyte for separator-free Zn-halogen batteries with customizable electron transfer.Robust hydrogen bonding of hydroxyl groups in SiO_(2)with fluorinated moieties in PVDF-hfp regulates Zn^(2+)solvation and suppresses H_(2)O activity,while multi-channels formed by microcracks and interparticle gaps not only enhance mass transfer but also buffer interfacial electric field,jointly enabling a durable Zn plating/stripping.Effective confinement of intermediates also ensures the high reversibility across single-(I^(-)/I0),double-(I^(-)/I0/I^(-)),and triple-(I^(-)/I0/I^(-),Cl-/Cl0)electron transfer mechanisms at cathode,as evidenced by the double-electron transfer systems exhibiting a low capacity decay rate of 0.02‰over 4500 cycles at 10 mA cm^(-2)and a high areal capacity of 11.9 mAh cm^(-2)at 2 mA cm^(-2).This work presents a novel“container engineering”approach to halogen-ion electrolyte design and provides fundamental insights into the relationships between redox reversibility and reaction kinetics.
基金National Natural Science Foundation of China(No.12071370)。
文摘The bipartite containment control problem for heterogeneous nonlinear multi-agent systems(HNMASs)within multi-group networks under signed digraphs is investigated,where the first-order and second-order nonlinear dynamic agents belong to distinct groups.Interactions are cooperative-antagonistic within each group and sign-in-degree balanced across the inter-groups.Firstly,a state feedback control protocol is designed to ensure that the trajectories of followers in diverse groups can converge to distinct convex hulls formed by their corresponding leaders,respectively.As an extension,the bipartite control problem with time-variant formation for the multi-agent system(MAS)is also considered,and a corresponding control protocol with formation compensation vectors is given.Finally,in view of Lyapunov stability theory and matrix inequality,the sufficient conditions for realizing the bipartite containment control are obtained,and several simulations are provided to verify the validity of the above methods.
文摘Established in 2019,the Shandong Port Group(SPG)comprises four port groups(Qingdao Port,Rizhao Port,Yantai Port,and Bohaiwan Port)and 12 business segments.SPG connects 3,345 kilometers of coastline within Shandong Province.Its cargo throughput has consistently ranked first globally for many years,and its container volume growth ranks second globally,forming a port cluster covering the entire industrial chain.
基金funded by Wellcome 4ward North(Ref:216340/Z/19/Z)ARUK Yorkshire Network Centre Small Grant Scheme,ARUK Preparatory Clinical Fellowship scheme(Ref:ARUK-PCRF2016A-1)+3 种基金Academy of Medical Sciences Starter Grants for Clinical Lecturers Scheme(Ref:SGL028\1097),Parkinson’s UK(Ref:F1301)Michael J Fox Foundation(Ref:005021),Australian Research Council(CE200100012)European Union Seventh Framework Programme(Ref:FP7/2007-2013)under grant agreement no.601055the NIHR Sheffield Biomedical Research Centre award(NIHR 203321)(to SMB).
文摘Alzheimer’s disease(AD)is the most common form of dementia characterized pathologically by the deposition of amyloid plaques and hyperphosphorylated tau containing neurofibrillary tangles.The disease presents clinically with progressive memory loss and disruption of cognitive function.Currently,there is no cure for AD;recent advances in the therapeutics aimed at clearing the amyloid protein from the brain have led to potential disease stabilization,however,this does not prevent eventual disease progression(Cummings et al.,2024).
文摘Crystallized lithium fluoride(LiF)melts at 848℃ upon heating,and evaporates subsequently at a remarkably high temperature of 1673℃,characterizing its excellent thermally stability as one of the most representative metal halides.The marriage between Li F and rechargeable batteries dates back to early activities related to the electrochemical properties of lithium metal(Li°)negative electrodes,in which the nonaqueous electrolytes containing fluorinated salts were generally employed,e.g.,lithium tetrafluoroborate(LiBF_(4)),lithium hexafluoroarsenate(LiAsF_(6)),lithium trifluoromethanesulfonate(CF_(3)SO_(3)Li)[1].
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF),funded by the Ministry of Education(RS-2023-00248378 and NRF-2020R1A6A1A03043708).
文摘Objectives:Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor(ER)α-positive breast cancer;however,resistance remains a significant clinical challenge.This study aims to investigate the molecular mechanisms of tamoxifen resistance in ERα-positive breast cancer,with particular focus on the role of SET Domain Containing 1A(SETD1A)-driven forkhead box A2(FOXA2)as a key regulator of this resistance.Methods:FOXA2 expression and its regulation by SETD1A were assessed via(quantitative polymerase chain reaction),western blotting,transcriptome profiling,and chromatin immunoprecipitation analyses.The effects of FOXA2 on cell proliferation,migration,invasion,and cancer stem cell traits were evaluated using small interfering RNA(siRNA)-mediated silencing.Clinical relevance was examined by analyzing patient datasets and tumor tissue microarrays.Results:FOXA2 expression was significantly elevated in tamoxifen-resistant(TamR)and ERα-negative breast cancer cells compared to that in ERα-positive MCF-7 cells,regardless of tamoxifen treatment or ERαdepletion.Transcriptome and chromatin immunoprecipitation analyses revealed that SETD1A,a histone methyltransferase,directly regulated FOXA2 expression.Functionally,FOXA2 knockdown inhibited the proliferation,migration,invasion,and cancer stem cell properties of TamR cells while restoring tamoxifen sensitivity.High FOXA2 expression was correlated with poor survival and reduced responsiveness to tamoxifen in patients with ER-positive breast cancer.Conclusion:Our findings identified FOXA2 as a key mediator of tamoxifen resistance regulated by SETD1A and suggested that targeting the SETD1A-FOXA2 axis may offer a novel strategy for overcoming endocrine resistance in breast cancer.
基金supported by the Foundation Project:National Natural Science.Foundation of China(Nos.:82460249,82100417,81760094)The Foundation of Jiangxi Provincial Department of Science and Technology Outstanding Youth Fund Project(20212BAB206022,20242BAB23080).
文摘Objective:Leucine-rich alpha-2 glycoprotein 1(Lrg1)could regulate diverse cells in cerebral ischemiareperfusion.Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors.Method:The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing(scRNA-seq)data in middle cerebral artery occlusion reperfusion(MCAO/R).Monocle2 mapped endothelial differentiation paths.Gene set enrichment analysis(GSEA)analyzed endothelial subcluster variations.Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3(Zmiz1-Fzd3)promoter interaction.Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid.Polymerase chain reaction(PCR)and western blotting assessed MCAO/R or Zmiz1 overexpression effects on Fzd3-related mRNA and proteins.A retroviral vector carrying Zmiz1 was injected into the brains of mice to study its effect on Fzd3.Result:Lrg1−/−mice exhibited elevated cell adhesion proteins and decreased microvascular leakage after MCAO/R.CSOmap showed widened astrocyte spacing in thesemice.RSS revealed Zmiz1 overexpression inMCAO/R+Lrg1−/−mice.MCAO/R and pcDNA3-Zmiz1 transfection both enhanced luciferase activity with Fzd3,indicating Zmiz1 binding to Fzd3.Retroviral Zmiz1 injection or knockdown disrupted ischemic brain tight junctions,highlighting Zmiz1’s key role in blood-brain barrier protection,likely through Fzd3 pathway modulation.Conclusion:The findings indicate Lrg1 knockout induces endothelial differentiation by activating Zmiz1,which is crucial for maintaining blood-brain barrier function,possibly via modulating the Fzd3 pathway.
基金supported by the Jilin Province Health Science and Technology Ability Improvement Project(2023JL057).
文摘Objective:Triple-negative breast cancer(TNBC)is highly aggressive and lacks an effective targeted therapy.This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2(ZMIZ2)and minichromosome maintenance complex component 3(MCM3)in TNBC progression.Methods:The relationship between ZMIZ2 expression and clinical characteristics of TNBC was investigated.In vitro and in vivo experiments were performed to investigate the role of ZMIZ2 dysregulation in TNBC cell malignant behaviors.The regulatory relationship between ZMIZ2 and MCM3 was also explored.Transcriptome sequencing was performed to elucidate possible mechanisms underlying the ZMIZ2/MCM3 axis in TNBC.Results:High ZMIZ2 expression levels were associated with the malignant degree of TNBC.ZMIZ2 overexpression promoted TNBC cell proliferation,migration,and invasion;inhibited apoptosis;and induced G1 phase cell cycle arrest,whereas knockdown of ZMIZ2 had the opposite effect.ZMIZ2 directly targeted and positively regulated MCM3 expression.MCM3 knockdown reversed the effect of ZMIZ2 overexpression on TNBC tumor growth both in vitro and in vivo.High MCM3 expression levels were linked to the degree of malignancy and poor prognosis in TNBC.The differentially expressed genes associated with the ZMIZ2/MCM3 axis were significantly enriched in multiple pathways,such as the mitogen-activated protein kinase(MAPK),mechanistic target of rapamycin(mTOR),Wnt,and Ras signaling pathways,as verified by The Cancer Genome Atlas data.Conclusions:ZMIZ2 and MCM3 were highly expressed in TNBC.ZMIZ2 promoted the development by positively regulating MCM3 expression.Key pathways,such as the Ras/MAPK,phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mTOR,and Wnt signaling pathways,may be key downstreammechanisms.
