摘要
Alzheimer’s disease(AD)is the most common form of dementia characterized pathologically by the deposition of amyloid plaques and hyperphosphorylated tau containing neurofibrillary tangles.The disease presents clinically with progressive memory loss and disruption of cognitive function.Currently,there is no cure for AD;recent advances in the therapeutics aimed at clearing the amyloid protein from the brain have led to potential disease stabilization,however,this does not prevent eventual disease progression(Cummings et al.,2024).
基金
funded by Wellcome 4ward North(Ref:216340/Z/19/Z)
ARUK Yorkshire Network Centre Small Grant Scheme,ARUK Preparatory Clinical Fellowship scheme(Ref:ARUK-PCRF2016A-1)
Academy of Medical Sciences Starter Grants for Clinical Lecturers Scheme(Ref:SGL028\1097),Parkinson’s UK(Ref:F1301)
Michael J Fox Foundation(Ref:005021),Australian Research Council(CE200100012)
European Union Seventh Framework Programme(Ref:FP7/2007-2013)under grant agreement no.601055
the NIHR Sheffield Biomedical Research Centre award(NIHR 203321)(to SMB).
