Background:Hemodialysis(HD) per se is a risk factor for thrombosis.Considering the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the...Background:Hemodialysis(HD) per se is a risk factor for thrombosis.Considering the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training model.The aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this molecule.Methods:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of <15 mL/min/1.73 m2).The RE+BFR session consisted of 50% arterial occlusion pressure during 50 min sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning specialist.Results:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD vintage.Furthermore,RE+BFR significantly increases D-dimer after 4 h.Patients with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.展开更多
目的探讨子宫动脉多普勒血流参数联合血清甲胎蛋白(AFP)对子痫前期及围生儿不良结局的预测价值。方法前瞻性选择2022年7月至2024年9月肇庆市第一人民医院收治的100例子痫前期患者作为观察组,根据患者病情严重程度分为轻度子痫前期组68...目的探讨子宫动脉多普勒血流参数联合血清甲胎蛋白(AFP)对子痫前期及围生儿不良结局的预测价值。方法前瞻性选择2022年7月至2024年9月肇庆市第一人民医院收治的100例子痫前期患者作为观察组,根据患者病情严重程度分为轻度子痫前期组68例和重度子痫前期组32例,并选择健康孕妇50例作为对照组,比较三组孕妇的子宫动脉血流参数阻力指数(RI)、搏动指数(PI)、收缩期/舒张期流速比值(S/D)、血清AFP水平及围生儿不良结局。采用受试者工作特征(ROC)曲线评价子宫动脉多普勒血流参数联合血清AFP对子痫前期及围生儿不良结局的预测价值。结果重度子痫前期组孕妇的RI、PI、S/D水平分别为0.71±0.15、1.36±0.23、3.47±0.41,明显高于轻度子痫前期组的0.63±0.10、1.15±0.17、2.57±0.34,和对照组的0.55±0.06、0.84±0.12、2.30±0.25,血清AFP水平为(34.36±3.92)μg/L,明显低于轻度子痫前期组的(45.21±4.70)μg/L和对照组的(49.20±6.85)μg/L,且轻度子痫前期组孕妇的血清RI、PI、S/D水平明显高于对照组,血清AFP水平明显低于对照组,差异均有统计学意义(P<0.05);重度子痫前期组孕妇的分娩孕周、胎盘重量、新生儿体质量及1 min Apgar评分分别为(33.74±2.95)周、(589.92±40.25)g、(2520.18±380.47)g、(7.40±0.53)分,明显高于轻度子痫前期组的(37.13±3.20)周、(630.15±50.12)g、(2750.25±395.24)g、(7.88±0.67)分和对照组的(40.22±2.03)周、(690.95±66.53)g、(3210.84±400.58)g、(8.91±0.73)分,且轻度子痫前期组孕妇的分娩孕周、胎盘重量、新生儿体质量及1 min Apgar评分明显高于对照组,差异均有统计学意义(P<0.05);ROC曲线分析结果显示,RI、PI、S/D、AFP的曲线下面积(AUC)为0.801、0.792、0.788、0.687,敏感度分别为85.74%、84.15%、82.63%、87.50%,特异性分别为75.33%、72.15%、71.88%、87.00%,子宫动脉多普勒血流参数联合血清AFP的AUC、敏感度、特异性分别为0.885、91.27%、90.55%,提示子宫动脉多普勒血流参数联合血清AFP检测对子痫前期及围生儿不良结局具有较高的预测价值。结论子宫动脉多普勒血流参数联合血清AFP对子痫前期及围生儿不良结局的预测价值较高,值得临床推广应用。展开更多
基金supported by a grant provided by the Coordenacao de Aperfeicoamento de Pessoal de Nível Superior-Brazil-Finance Code 001 and National Council for Scientific and Technological Developmentfinanced in part by the Conselho Nacional de Desenvolvimento Científico e Tecnológico and Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil--Finance Code 001funded by the Fundacao de Apoio à Pesquisa do Distrito Federal with grants from demanda espontanea-Edital 09/2022
文摘Background:Hemodialysis(HD) per se is a risk factor for thrombosis.Considering the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training model.The aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this molecule.Methods:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of <15 mL/min/1.73 m2).The RE+BFR session consisted of 50% arterial occlusion pressure during 50 min sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning specialist.Results:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD vintage.Furthermore,RE+BFR significantly increases D-dimer after 4 h.Patients with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.
文摘目的探讨子宫动脉多普勒血流参数联合血清甲胎蛋白(AFP)对子痫前期及围生儿不良结局的预测价值。方法前瞻性选择2022年7月至2024年9月肇庆市第一人民医院收治的100例子痫前期患者作为观察组,根据患者病情严重程度分为轻度子痫前期组68例和重度子痫前期组32例,并选择健康孕妇50例作为对照组,比较三组孕妇的子宫动脉血流参数阻力指数(RI)、搏动指数(PI)、收缩期/舒张期流速比值(S/D)、血清AFP水平及围生儿不良结局。采用受试者工作特征(ROC)曲线评价子宫动脉多普勒血流参数联合血清AFP对子痫前期及围生儿不良结局的预测价值。结果重度子痫前期组孕妇的RI、PI、S/D水平分别为0.71±0.15、1.36±0.23、3.47±0.41,明显高于轻度子痫前期组的0.63±0.10、1.15±0.17、2.57±0.34,和对照组的0.55±0.06、0.84±0.12、2.30±0.25,血清AFP水平为(34.36±3.92)μg/L,明显低于轻度子痫前期组的(45.21±4.70)μg/L和对照组的(49.20±6.85)μg/L,且轻度子痫前期组孕妇的血清RI、PI、S/D水平明显高于对照组,血清AFP水平明显低于对照组,差异均有统计学意义(P<0.05);重度子痫前期组孕妇的分娩孕周、胎盘重量、新生儿体质量及1 min Apgar评分分别为(33.74±2.95)周、(589.92±40.25)g、(2520.18±380.47)g、(7.40±0.53)分,明显高于轻度子痫前期组的(37.13±3.20)周、(630.15±50.12)g、(2750.25±395.24)g、(7.88±0.67)分和对照组的(40.22±2.03)周、(690.95±66.53)g、(3210.84±400.58)g、(8.91±0.73)分,且轻度子痫前期组孕妇的分娩孕周、胎盘重量、新生儿体质量及1 min Apgar评分明显高于对照组,差异均有统计学意义(P<0.05);ROC曲线分析结果显示,RI、PI、S/D、AFP的曲线下面积(AUC)为0.801、0.792、0.788、0.687,敏感度分别为85.74%、84.15%、82.63%、87.50%,特异性分别为75.33%、72.15%、71.88%、87.00%,子宫动脉多普勒血流参数联合血清AFP的AUC、敏感度、特异性分别为0.885、91.27%、90.55%,提示子宫动脉多普勒血流参数联合血清AFP检测对子痫前期及围生儿不良结局具有较高的预测价值。结论子宫动脉多普勒血流参数联合血清AFP对子痫前期及围生儿不良结局的预测价值较高,值得临床推广应用。
