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血流限制训练改善前交叉韧带重建后患者膝关节功能及肌力的Meta分析

Meta-analysis of blood flow restriction training to improve knee function and muscle strength in patients after anterior cruciate ligament reconstruction
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摘要 目的:血流限制训练是一种提高肌肉力量、促进肌肉肥大的低负荷训练方法,其特点与前交叉韧带重建后的康复需求相符合,但实际康复效果仍不清晰。因而此文系统评价血流限制训练对前交叉韧带重建后患者的膝关节康复效果,比较血流限制训练与传统抗阻康复训练对前交叉韧带重建后患者膝关节康复效果的差异。方法:通过计算机检索EBSCO、Embase、PubMed、The Cochrane Library、Web of Science英文数据库和CBM、CNKI、VIP、WanFang Data中文数据库及美国临床试验数据库(ClinicalTrials.gov),搜集采用血流限制训练对前交叉韧带重建后患者膝关节康复的随机对照试验,检索时限均为从建库至2024-10-31。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4软件和Stata 14.0软件进行Meta分析。结果:①共纳入11篇研究,包括317例患者;②Meta分析结果显示,血流限制训练在改善前交叉韧带重建后患者膝关节肌力[SMD=0.75,95%CI(0.46,1.04),P<0.00001]、膝关节周围肌肉量[SMD=0.48,95%CI(0.30,0.66),P<0.00001]、膝关节功能[SMD=2.69,95%CI(1.32,4.07),P=0.0001]方面均优于传统抗阻康复训练组;③亚组分析显示,当每周训练次数≥3次时,膝关节周围肌肉量[SMD=0.43,95%CI:(0.23,0.63),P<0.0001]更优于传统抗阻康复训练组。结论:血流限制训练比传统抗阻康复训练更能改善前交叉韧带重建后患者的膝关节肌力、膝关节周围肌肉量和膝关节功能;同时在康复周期内采用每周3次及以上的血流限制训练能更好地提高膝关节周围肌肉量。 OBJECTIVE:Blood flow restriction training is a low-load training method designed to enhance muscle strength and promote muscle hypertrophy.Its characteristics align well with the rehabilitation needs following anterior cruciate ligament reconstruction.However,its actual efficacy remains unclear.Therefore,this study systematically evaluated the effectiveness of blood flow restriction training on knee joint rehabilitation in patients after anterior cruciate ligament reconstruction and compared the differences in knee rehabilitation outcomes between blood flow restriction training and traditional resistance training.METHODS:By searching EBSCO,Embase,PubMed,The Cochrane Library,Web of Science English databases,CBM,CNKI,VIP,WanFang Data Chinese databases and clinical trial center database(ClinicalTrials.gov),the randomized controlled trials of knee rehabilitation after anterior cruciate ligament reconstruction were collected.The search time was from the establishment of the database to October 31,2024.Two reviewers independently screened literature,extracted data,and assessed the risk of bias of included studies.The meta-analysis was performed using RevMan 5.4 software and Stata 14.0 software.RESULTS:(1)A total of 11 studies involving 317 patients were included.(2)Meta-analysis results showed that blood flow restriction training was superior to traditional resistance rehabilitation training group in improving knee muscle strength[standardized mean difference(SMD)=0.75,95%confidence interval(CI)(0.46,1.04),P<0.00001],muscle mass around knee joint[SMD=0.48,95%CI(0.30,0.66),P<0.00001]and knee joint function[SMD=2.69,95%CI(1.32,4.07),P=0.0001].(3)Subgroup analysis showed that the muscle mass around the knee joint[SMD=0.43,95%CI(0.23,0.63),P<0.0001]was better than that of the traditional resistance rehabilitation training group when the training times were≥3 times per week.CONCLUSION:Blood flow restriction training demonstrates superior efficacy compared to traditional resistance training in improving knee muscle strength,peri-knee muscle mass,and knee function in patients following anterior cruciate ligament reconstruction.Furthermore,implementing blood flow restriction training at a frequency of three or more sessions per week during the rehabilitation period leads to more significant enhancements in peri-knee muscle mass.
作者 陈子昂 李秦陇 吴雪 周越 Chen Ziang;Li Qinlong;Wu Xue;Zhou Yue(Beijing Sport University,Beijing 100084,China)
机构地区 北京体育大学
出处 《中国组织工程研究》 北大核心 2026年第29期7680-7687,共8页 Chinese Journal of Tissue Engineering Research
基金 国家重点研发计划(2018YFF0300801),“冬季项目专项、体能和康复训练关键技术集成研究与应用”,项目负责人:周越。
关键词 血流限制训练 前交叉韧带重建 膝关节肌力 膝关节功能 随机对照试验 blood flow restriction training anterior cruciate ligament reconstruction knee muscle strength knee function randomized controlled trial
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