摘要
目的观察非增殖型糖尿病视网膜病变(nonproliferative diabetic retinopathy,NPDR)肝肾阴虚证治疗中六味地黄汤加味联合针灸对其视盘血流及视功能的影响。方法选取NPDR肝肾阴虚证患者86例,经Excel产生随机序列号将其分为对照组和试验组,每组43例。两组均采用常规治疗,对照组另采用针灸治疗,试验组在对照组基础上增用六味地黄汤加味治疗。比较治疗前后两组中医证候积分、视盘血流及视功能;比较两组治疗效果及不良反应。结果两组各脱落2例,最终均纳入41例。治疗后试验组主症、次症积分及总积分,最佳矫正视力(best corrected visual acuity,BCVA)、对数最小分辨角(logarithm of the minimum angle of resolution,LogMAR)均低于对照组(P<0.05),颞下、颞上、上颞、上鼻、下鼻、下颞、鼻上、鼻下视盘旁放射状毛细血管网血流密度(peripapillary telangiectasia vessel density,PPVD)值均高于对照组(P<0.05);试验组治疗总有效率高于对照组(P<0.05);对照组、试验组不良反应发生率比较,差异无统计学意义(P>0.05)。结论六味地黄汤加味联合针灸可减轻NPDR中医症状,改善视盘血流、视功能及临床疗效,且不会导致不良反应增加。
Objective To observe the effects of Modified Liuwei Dihuang Decoction(六味地黄汤加味)combined with acupuncture on optic disc blood flow and visual function in patients with liver-kidney Yin deficiency syndrome of non-proliferative diabetic retinopathy(NPDR).Methods Eighty-six patients with liver-kidney Yin deficiency syndrome of NPDR were randomly divided into control group and experimental group,each with 43 cases,using random number generation by Excel.Both groups received routine treatment,with the control group additionally receiving acupuncture treatment,and the experimental group receiving Modified Liuwei Dihuang Decoction based on the treatment of the control group.The changes in traditional Chinese medicine(TCM)symptom scores,optic disc blood flow and visual function before and after treatment in both groups were compared.The therapeutic effects and adverse reactions between the two groups were compared.Results Two cases were lost to follow-up in each group,and ultimately 41 cases were included in both.After treatment,the main symptom scores,secondary symptom scores,total scores and best-corrected visual acuity(BCVA)in logarithm of the minimum angle of resolution(LogMAR)in the experimental group were higher than those in the control group(P<0.05),the blood flow density(PPVD)values at the temporal inferior,temporal superior,nasal superior,nasal inferior,inferior temporal,inferior nasal,superior nasal and inferior nasal quadrants were higher than those in the control group(P<0.05).The total effective rate in the experimental group was higher than that in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the control group and the experimental group(P>0.05).Conclusion Modified Liuwei Dihuang Decoction combined with acupuncture can alleviate TCM symptoms of NPDR,improve optic disc blood flow,visual function and clinical efficacy,and does not lead to an increase in adverse reactions.
作者
李昊洋
刘莉
刘会荣
张风梅
LI Haoyang;LIU Li;LIU Huirong;ZHANG Fengmei(Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450003,Henan,China;Second Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450003,Henan,China)
出处
《中华中医药学刊》
北大核心
2026年第2期70-74,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家重点研发计划项目(2022YFC3502504)
中国中医科学院科技创新工程重点协同攻关项目(CI2022C001)。
关键词
非增殖性糖尿病视网膜病变
肝肾阴虚证
六味地黄汤
针灸
视盘血流
视功能
non-proliferative diabetic retinopathy
liver-kidney Yin deficiency syndrome
Liuwei Dihuang Decoction(六味地黄汤)
acupuncture
optic disc blood flow
visual function
