摘要
本文系统测定了胃液蛋白质浓度和CEA水平,结果表明:胃癌患者胃液蛋白质浓度显著升高,敏感性65.0％,特异性86.7％,准确性81.6％。胃癌患者CEA水平升高显著,敏感性58.8％,特异性83.6％,准确性79.0％。用判别函数y=0.446·PQA+0.003·CEA将二者联合起来,使胃癌的敏感性提高为82.4％,特异性86.0％,准确性85.0％,2例早期胃癌均阳性。
Protein quantitative analysis(PQA)and carcinoembryonic antigen(CEA)in gastric juice were investi-gated simultaniously in 34 patients with gastric cancer, 82 patients with benign gastric lesions and 31controls. Normal value of PQA was 4.56±1.93mg/ml, gastric cancer was 9.71±4 .61mg/ml (p<0.01).The sensivity was 65.0% and the specificity was 86.7%. Normal leve1 of CEA in gastric juice was68.14±71.00ng/ml, it was evaluated to 560.96±668.10ng/ml in gastric cancer(p<0 .01) .CEA level wasraised gradually following the advance of precancerous lesions. Sensitivity of CEA was 58.8K and sp-ecificity was 83.6%. The two data of PQA and CEA were analyzed with ANALYST software and adiscriminating function Y=0 .446. PQA+0.003.CEA was established. The result was obtained with thisfunction, sensitivity of the test was 82.4K, specificity and accuracy were 86.0% and 85.0% respecti-vely, two early gastric cancers were all positive. This result may be useful in a screening program andclinical diagnosis of gastric cancer.
出处
《北京医科大学学报》
CSCD
1993年第1期44-46,共3页
Journal of Peking University(Health Sciences)
关键词
蛋白
定量分析
癌胚抗原
胃肿瘤
Gastric cancer
Protein quantitative analysis
Carcinoembryonic antigen
Discriminating
