摘要
目的 :研究委陵菜对四氯化碳 (CCl4)致小鼠急性肝损伤的保护作用。方法 :用委陵菜给小鼠灌胃 7天 ,观察对四氯化碳致小鼠肝损伤所引起血清谷丙转氨酶和谷草转免酶升高、肝脂质过氧化物含量的影响。结果 :委陵菜能明显降低模型组的血清转氨酶、肝脂质过氧化物含量。结论
Objective:To investigate the protective effects of the ethanolic extract from Potentilla chinensis Ser.(PS) on mice acute hepatic injury induced by CCl-4.Methods:Mice were administracted with the ethanolic extract from Potentilla chinensis Ser.ig.5g·kg -1,3g·kg -1,1.8g·kg -1 daily for 7d respectively after the hepatic injury was induced by ip.10ml·kg -1 0.1% carbon tetrachloride.After 16h,serum alanine aminotransferase(ALT and AST) activity were measured,and Maleic Dialdehyde (MDA) in liver was detected.Results:The ethanolic extract from PS significantly reduce the level of serum ALT and AST,and inhabited lipoperoxidation in liver.Conclusion:Potentilla chinensis ser.showed protective effects on mice acute hepatic injury.
出处
《辽宁中医杂志》
CAS
2004年第5期422-423,共2页
Liaoning Journal of Traditional Chinese Medicine
基金
辽宁省教育厅基金项目
关键词
委陵菜
四氯化碳
脂质过氧化
急性肝损伤
Potentilla chinensis Ser.
carbon tetrachloride(CCl-4)
lipoperoxidation
acute hepatic injury
