摘要
目的 :研究三叶委陵菜对四氯化碳 (CCl4)致小鼠急性肝损伤的保护作用。方法 :用三叶委陵菜给小鼠灌胃 7d,观察对四氯化碳致小鼠肝损伤所引起血清谷丙转氨酶和谷草转氨酶升高、肝线粒体脂质过氧化物含量的影响。结果 :三叶委陵菜能明显降低模型组的血清转氨酶、肝线粒体脂质过氧化物含量。结论
Objective: To investigate the protective effects of the ethanolic extract from Potentilla freyniana Bornm. (PB) on mice acute hepatic injury induced by CCl 4.Methods:Mice were administrated with the ethanolic extract from Potentilla freyniana Bornm., ig.50 g·kg -1 ,25 g·kg -1 ,12.5 g·kg -1 daily for 7 d respectively after the hepatic injury was induced by ip. 10 ml·kg -1 0.1% carbon tetrachloride. After 16 h,serum alanine aminotransferase (ALT and AST) activity were measured, and thiobarbituric acid reactive substance (TBARS) in hepatic mitochondria was detected.Results:The ethanolic extract from PB significantly reduced the level of serum ALT and AST, and inhibited lipoperoxidation in hepatic mitochondria.Conclusion: Potentilla freyniana Bornm. showed protective effects on mice acute hepatic injury.
出处
《时珍国医国药》
CAS
CSCD
2001年第4期294-295,共2页
Lishizhen Medicine and Materia Medica Research
关键词
三叶委陵菜
四氯化碳
脂质过氧化
急性肝损伤
中药
药理
Potentilla freyniana Bornm.
Carbon tetrachloride(CCl 4)
Lipoperoxidation
Acute hepatic injury
