摘要
目的:观察委陵菜防治大鼠肝纤维化的疗效并探讨其作用机制。方法:以四氯化碳制备大鼠肝纤维化模型,观察委陵菜对肝纤维化大鼠肝功能、血透明质酸(HA)、层黏连蛋白(LN)、III型前胶原(PCIII)、IV型胶原(CIV)及超氧化物歧化酶(SOD)、丙二醛(MDA)含量变化及观察肝脏显微结构改变。结果:委陵菜治疗组与模型对照组比较,碱性磷酸酶(ALP)、MDA、HA、LN、PCIII、CIV明显下降(P<0.01和P<0.05),血清白蛋白(ALB)、SOD明显增高(P<0.01);PT缩短;光镜下肝纤维化程度减轻。结论:委陵菜具有保肝、延缓肝纤维化形成的作用,其作用机制可能与其抗氧化作用有关。
Objective ：To observe the curative effect of the ethanolic estract from Potentilla chinensis（PS） on rat hepatic fibrosis and to discuss it saction mechanism. Methods ：The rat hepatic fibrosis model was made with 40% Carbon Tetrachloride （CC14 ）0.5mL/100g intraperitoneal injection. PS treatment group was treated with PSSg/（ kg · d）intragastric administration. The content Changes of hepatic function, blood hyaluronateacid（HA） , superoxidedismutes（SOD） and malondialdehyde（ MDA）, and the hepatic microstructure changes were observed. Results ：PS treatment group Compared with model control group, the alkaline-phosphatase （ ALP）, M DA and HA lowered obviously （ P 〈 0.01 and P 〈 0.05 ）, the serum albumin （ALB） and SOD heightened obviously （ P 〈 0.01 ） , and the hepatic fibrosis degree lightened under lightmicroscope. Conclusion： PS has the action of protecting liver and delaying hepatic fibrosis formation, the mechanism maybe related with its santioxidation.
出处
《辽宁中医杂志》
CAS
北大核心
2007年第8期1157-1159,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
委陵菜
四氯化碳
肝纤维化
实验研究
potentilla chinensis ser
carbon tetrachloride （ CC14 ）
hepatic fibrosis
experimental study
