摘要
无溶剂参与的Michael加成反应 ,具有收率高 ,选择性强 ,操作简捷和成本低廉的优点 ,尤其有利于对环境的保护 .在无溶剂条件下 ,各种高效的碱性、酸性催化剂 ,特别是手性催化剂的使用 ,不仅实现了有机合成化学方法学的新突破 ,也拓宽了该类反应的应用范围 .简要综述了无溶剂Michael加成反应的新近研究进展 ,详细讨论了碱性。
Due to its excellent yield, high selectivity, convenient operation and cost effectiveness, the echo friendly reaction of the solvent free Michael addition has been extensively explored recently. Some new synthetic methods have been achieved by employing various highly efficient catalysts, which will definitely broaden the application of this reaction. Recent development of solvent free Michael addition is reviewed in this paper. Many successful instances are discussed in detail, which are prompted by basic, acidic catalysts or even under catalyst free conditions.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第6期600-608,共9页
Chinese Journal of Organic Chemistry
