期刊文献+

舒巴坦的生产工艺改进 被引量:5

Improvement on the synthetic process of sulbactam
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摘要 通过改变氧化及还原反应的介质和其他反应条件 ,对舒巴坦的生产工艺进行了改进 。 The synthetic method of sulbactam,mainly involving the reaction medium and condition about oxidation and reduction,was developed.The overall yield and the quality of the product was also improved.
出处 《中国药物化学杂志》 CAS CSCD 2004年第3期180-181,共2页 Chinese Journal of Medicinal Chemistry
关键词 药物化学 工艺改进 化学合成 舒巴坦 medicinal chemistry process improvement chemical synthesis sulbactam
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参考文献6

  • 1Pfizer Inc.7-(D-2-[ethylpiperazine-2,3-dione-1-carboxamido]-2-[4-hydroxyphenyl]acetamido)-3-([1-methyl-5-tetrazolyl]thiomethyl)-3-deacetoxymethylcephalosporanic acid and penicillanic acid 1,1-dioxide and pharmaceutical composition containing them[P].FR:24
  • 2Volkmann RA,Moore BS,Carroll RD,et al.Efficient preparation of 6,6-dihalopenicillanic acids,synthesis of penicillanic acid S,S-dioxide(sulbactam)[J].J Org Chem,1982,47(17):3344-3345.
  • 3Moore BS,Carroll RD,Volkmann RA.Penicillanic acid 1,1-dioxide and its ester and intermediate[P].US:4420426,1979-05-05.
  • 4Barth WE.6-Substituted penicillanic acid 1,1-dioxide compounds[P].US:4590073,1984-10-22.
  • 5游金莺 欧阳凯.β—内酰胺酶抑制剂—CP45899的工艺研究[J].中国抗生素杂志,1986,11(4):363-365.
  • 6任升俊 李正化.青霉烷砜酸的合成[J].医药工业杂志,1984,139(2):1-3.

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同被引文献23

  • 1邱方利,潘富友.舒巴坦钠的合成[J].化学世界,2006,47(2):99-101. 被引量:4
  • 2游金莺 欧阳凯.β—内酰胺酶抑制剂—CP45899的工艺研究[J].中国抗生素杂志,1986,11(4):363-365.
  • 3WIEDEMANN B, KLIEBE C, KRESDEN, et al. The epidemiology of β-lactamase [ J ]. J Antimicrob Chemother, 1989, 24(Suppl- B) :1.
  • 4SCHMALRECK A F , WILDFEUER A. In vitro activity against clinically important gram-positive and gram-negative b- acteria of sulbactam alone and in combination with am-picillin, cefotaxime, mezocillin and piperacillin [ J ]. Drug Res,1990(40) :1145 - 1155.
  • 5ENGLIKH AR. A β-lactamase inhibitor that extends the antibacterial spectrum of β- lactamase: Initial bacteriogical characterization [ J ]. Antimicr- ob Ag Chemother, 1978 (14) :414 -419.
  • 6LIVERMORE D M. Determinants of the activity of β-lactamase inhibitor combinations [ J ]. Journal of Antimicrobial chemotherapy, 1993,31 ( Sup-ph A) :9 -21.
  • 7COMIS D B, SANCHEZ N , GA-RCIA E A, JASANADA M B , ALVAREZ M. Fast high perform- ance liquid chromatogram p-hy method for in-process control of sulbactam[J].2003,498(1 - 2):1 -8
  • 8ACAR J F, MIUOZZI C. Role of β-lactamase in the resistance of gramnegative bacilli to β-lactam antibiotics[ J ]. Rev-InfectDis, 1986 ,8( 1 -5) :483.
  • 9Barth W E. 6-substituted penieillanie acid 1,1-dioxide compounds[ P]. US:d590073,1984-10-22.
  • 10Pfizerlnc. 7-( D-2-[ ethylpierazine-2,3-dione-1 -carbox-amido ] -2-[ 4-hydroxypheny ] acetamido ) -3-( [ 1 -methyl-5-tetrazolyl ] thiomerthyl)-3-deaeetoxymethyleephalosporanie acid and penieillanie acid 1,1-dioxide and pharmaceutical composition containing them [ P]. FR:2442453,1980-06-20.

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