摘要
目的 :探讨职业环境空气中铅浓度与铅接触人群肾功能的关系。方法 :测定 1 1家印刷厂 ,4家冶炼厂和 2家铅矿工作场所的空气铅浓度 ,并以尿糖、尿蛋白和尿沉渣为 1 1 90名铅接触人员作肾损害筛选检查 ,有一项以上损害者进一步作肾功能检查。将空气铅浓度与肾功能各项指标作多元线性相关分析。结果 :印刷厂空气铅为0 .0 7mg/m3 ,冶炼厂为 0 .2 6mg/m3 ,铅矿为 0 .6 6mg/m3 ,1 5 7人有一项以上肾功能损害占 1 3%。职业环境空气铅浓度与铅接触人员的肾功能指标的复相关系数R =0 .894 ,P <0 .0 0 1 ,决定系数R2 =0 .799,偏相关系数显示 ,空气铅与血铅、尿铅、Bun、Scr、尿糖、尿 β2 MG呈正相关 ,P值在 <0 .0 1～ 0 .0 0 1之间 ;与内生肌酐清除率呈负相关 ,r = 0 .1 8,P =0 .0 5 ,与尿蛋白、尿白蛋白和血清 β2 MG的相关系数无显著性意义。结论 :铅接触人员肾功能改变与空气铅浓度有关 。
Objective To determine the lead concentration in the air (pbA) at the workplace and the renal function of lead exposure workers.Methods The lead concentration in the air of 11 printing plants, 4 smelteries and 2 lead mines were measured. Screening urinalysis was performed in 1190 long term lead exposed workers with urine sugar, protein and sigements. It one of the three was abnormal,the workers were given examination of renal function. The relationship between pbA and renal function were confirmed by mutiple linear.Results The concentrations of pbA in the printing plants,smelteries and lead mines were 0.07 mg/m 3, 0.26 mg/m 3 and 0.66 mg/m 3 respectively.Altogether 157 cases had one and more abnormal renal function.The correlation of concentration PbA in the workplace and the renal function of lead exposure workers was shown ( R= 0.894 , P<0.001, R 2 =0.799). The correlation coefficient of skewness of showed that PbA and Bpb. Upb. Bun Scr Usug. Uβ2MG were positively correlated ( P < 0.01 ～0.001); Ccr was negatively correlated ( P =0.05). Upro, UNAG and Ualb were nonsignificant. Conclusion The lead concentration in the air at the workplace is related to the renal functions of lead exposure workers. It is important to decrease the lead environment and to prevent renal damage.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2004年第2期154-156,共3页
Journal of Central South University ：Medical Science
