摘要
目的探讨镉污染停止20余年后镉对接触人群的肾功能损害情况。方法于2001年,分别选择在张士灌区重、中、轻污染区及非污染区居住20a以上的39、65、57及42名居民为调查对象,测定其尿镉(UCd)、尿N-乙酰-β-D-氨基葡萄糖苷酶(UNAG)、尿β2-微球蛋白(UBMG)、尿视黄醇结合蛋白(URBP)及尿白蛋白(UALB)水平,这些指标的水平均用尿肌酐校正,并用几何均数进行比较。结果与1992年相比,轻、中、重污染区及非污染区居民尿镉水平明显下降,但重、中、轻污染区居民的UCd、UNAG、UBMG、URBP水平及UNAG的异常率均高于非污染区居民(均P<0.01);UNAG、UBMG、URBP、UALB水平和异常率均随尿镉水平的升高而增加,尤以尿镉水平达10μg/gCr以上明显高于5μg/gCr以下组。尿镉及肾损伤指标间均存在正相关(均P<0.01)。结论镉引起肾小管的不可逆损伤,严重者累及肾小球;尿镉水平可反映体内镉负荷及肾功能损害程度。
Objective To know the renal damage in cadmium （Cd） exposed residents in Cd polluted areas where polluted by Cd for 20 years. Methods The levels of urinary Cd （UCd）, N-acetyl-beta-D-glucosaminidase （UNAG）, 132-microglobulin （UBMG）, retinal binding protein （URBP）, and albumin （UALB） were measured in 39, 65, 57, and 42 residents lived in the severe-, moderate-, light-, and non-polluted area respectively for more. than 20 years. The test indexes were adjusted with urinary creatinine, and geometric means were statistically used. Results The levels of UCd in all subjects were obviously decreased compared with those in 1992, but the levels of UCd, UNAG, UBMG, and URBP and the abnormal rate of UNAG in residents in Cd-polluted areas were significantly higher than those in residents in non-polluted area （P〈0.01）. The levels and the abnormal rates of UNAG, UBMG, URBP, UALB increased as the levels of UCd incresed, so was that especially as it was over 10 μg/g Cr. There were a positive relationships between UCd and renal damage indexes （P〈0.O1）. Condusion Cadmium can induce nonreversible renal tubular damage, and glomerular damage may occur in some severe cases. The levels of UCd may reflect the body burden of Cd and the degree of renal damage.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2006年第3期202-204,共3页
Journal of Environment and Health
基金
欧共体INCO-DC项目资助(1335149L71430)
关键词
镉
环境污染
肾损害
Cadmium
Environmental pollution
Renal damage
