摘要
利用大鼠子宫内膜异位症 (内异症 )动物模型 ,采用逆转录聚合酶链反应 (RT PCR)技术 ,检测子宫内膜雌激素受体 (ER)和孕激素受体 (PR)mRNAs的表达 ,探讨内异症的发病机理及激素治疗的可能性。结果表明 ,内异症模型组大鼠异位内膜ER、PRmRNAs的表达低于在位内膜及对照组正常子宫内膜 ,与后两者比较差异有显著性意义(P <0 0 1 ) ;而模型组在位内膜ER、PRmRNAs的表达与正常对照组比较差异无显著性意义。内异症模型组异位内膜ER PRmRNA比值大于在位内膜及正常子宫内膜ER PRmRNA比值 (P <0 0 1 )。
To evaluate the expression of ER and PR mRNAs in rat endometrium tissue and to explore the pathogenesis of endometriosis. The expression of ER and PR mRNAs in ectopic endometrium was significantly lower than that in eutopic and normal endometrium ( P <0.01). No difference was observed between eutopic and normal endometium. Ratio of ER/PR mRNA in ectopic endometrium was higher than that in eutopic and in normal endometrium ( P <0.01). The result suggested that the increased ER played a vital role in the onset of endometriosis.
出处
《基础医学与临床》
CSCD
北大核心
2004年第2期192-195,共4页
Basic and Clinical Medicine
