摘要
本文报道用Ames试验、微核试验和精子畸形试验检测乳糖酶肠溶微囊致突变作用的结果:乳糖酶肠溶微囊浓度达2500μg/皿时,不论加与不加S_9代谢活化系统,对各菌株均无诱发回复突变作用。乳糖酶肠溶微囊1000mg/kg经口给药未能诱发小鼠骨髓多染红细胞微核和精子畸形率增加。
In present study Ames test, micronuclcous test and sperm abnormality test were used to identify the mutagcnises of lactase enteric-soluble microencapsules. The results showed that lactase enteric-soluble microencapsules produced no mutagenic effects in Ames test up to 2500 μg per dish on 4 strains with or without the presence of S9metabolic activation. Lactase enteric-soluble microencapsules did not increase the incidences of micronuclcated polychromatic crythrocytcs in the bone marrow and tthe percent of abnormal sperm in mice after oral treatment with 1000 mg / kg.
出处
《癌变·畸变·突变》
CAS
CSCD
1993年第4期27-29,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
乳糖酶
肠溶微囊
微核试验
致突变
lactase enteric-soluble microencapsulcs
Ames test
micronucleous test
sperm abnormality test.
