摘要
目的:制备BSA壳聚糖-海藻酸钠肠溶微囊并测试释放特性。方法:以微球的包封率为制备工艺优化指标,利用复凝聚法,通过正交实验筛选微球的最佳制备工艺条件制备微球。结果:最优条件为牛血清白蛋白和海藻酸钠的比例为1:6,壳聚糖的浓度为0.1%(g/ml),氯化钙的浓度为1%(g/ml)以及搅拌时间为1h。结论:BSA微囊在小肠中对蛋白有一定的缓释效果,突释效应不明显。
Objective： To prepare enteric microcapsules of BSA using the chitosan and sodium alginate as the matrix material, to test drug release characteristics. Methods： Complex coacervation was the method of preparation of microcapsules. The ratio of encapsulation acting as the preparation optimization target,the best technology was screened with orthogonal design. Results： The optimum formulation was BSA and Sodium algina chloride concentration of 1% （g/mL） Conclusion： Microcapsules of BSA has not evident. te ratio of 1：6, chitosan concentration of 0.1% （g/mL）, calcium and stirring time was lh in the most optimal conditions. some slow-release effect in the small intestine, burst effect were
出处
《金华职业技术学院学报》
2013年第3期89-92,共4页
Journal of Jinhua Polytechnic
关键词
肠溶微囊
牛血清白蛋白
复凝聚法
正交试验
enteric-coated microcapsules, bovine serum albumin （BSA）, complex coacervation,orthogonal experimental
