摘要
观察研究了大剂量维生素 C 和维生素 E 分别使用和共同使用时对 SD 大鼠摄入高脂高胆固醇饲料所致的高胆固醇血症的预防作用、采用60只成年 SD 大鼠,随机分成4组。即 VC 组[VC100mg/(kg.d)].VE 组[VE100mg/(kg.d)],VC 和 VE组[VC1000mg/(kg.d)]和[VE100mg/(kg.d)]以及对照组。各组大鼠摄入高脂高胆固醇饲料两个月,实验前和实验中每两周取血测血清总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C)。结果显示:1)大剂量 VC 可有效地阻止大鼠由于摄入高脂饲料引起的 HDL-C 下降,对照组为0.69mmol/L,VC 组为0.97mmol/L,差别有显著性意义。2)大剂量 VE 给药4周后,血清 HDL-C 值显著升高,由0.54mmol/L升至0.72mmol/L,但后期作用不明显。3)当 VC 和 VE 共同使用时,两种维生素的交互影响有非常显著性意义。
The preventive effect of VC and/or VE on the dietary hypercholesterolemia of rats had been observed.60 adult S-D rats were divided randomly into 4 group (n=12 in each),i.e.VC group [1000mg/(kg.d)],VE group [10mg(kg.d)], VC & VE group (VC 1000mg/kg.d & VE100mg/kg.d) and control.All 4 groups were fed with high fat diet (95% general diet, 1% cholesterol,0.5% choline and 3.5% lard) and water ad libitum for two months.The result showed that: 1) the decrease of HDL-C caused by dietary high fat feed in rats could be obstructed with large doses of VC,so there was a preventive effect on experi- mental hypercholesterolemia;2) the values of serum HDL-C of rats were increased obviously after large doses VE were given for 4 weeks,although the effect was no of significance on the late stage;3) the intereaction of VC and VE was very significant.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1992年第2期17-21,共5页
Journal of Jinan University(Natural Science & Medicine Edition)
