摘要
目的:探讨黄粉虫油对高脂血症小鼠血脂水平及抗氧化能力的影响。方法:以高脂饲料喂养雄性ICR小鼠,建立高脂血症模型,以不同剂量(5、10、20mL/(kg.d))的黄粉虫油对小鼠进行灌胃,观察各实验组小鼠血脂水平和肝脏抗氧化能力的变化情况。结果:黄粉虫油能显著降低高脂血症小鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)浓度,升高高密度脂蛋白胆固醇(HDL-C)的浓度,同时动脉粥样硬化指数(AI)亦显著降低;黄粉虫油能降低小鼠肝脏丙二醛(MDA)含量,增加肝脏过氧化氢酶(CAT)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)的活性,提高肝脏总抗氧化(T-AOC)能力。结论:黄粉虫油具有调节血脂和增强抗氧化功能的作用。
Objective： To explore the effect of Tenebrio molitor oil on blood lipid and antioxidant function in ICR male mice with hyperlipidemia.Methods： High fat diet was used to create a hyperlipidemic model.Fifty healthy male ICR mice were randomly divided into 5 groups of 10 each： normal control group（fed basal diet）,high fat model group（fed high fat diet） and low-,middle-and high-dose Tenebrio molitor oil groups（fed high fat diet and administered intragastrically with Tenebrio molitor oil at doses of 5,10 mL/（kg·d） and 20 mL/（kg·d）,respectively）.After 30 consecutive days of intragastric administration,all the mice were measured for their body weight,liver index,blood lipid levels and antioxidant function in liver.Results： Tenebrio molitor oil could reduce serum total cholesterol（TC）,triglyceride（TG）,and low-density lipoprotein cholesterol（LDL-C） levels as well as arteriosclerosis index（AI）,and increase high-density lipoprotein cholesterol（HDL-C） level.It could also reduce the content of malondialdehyde（MDA） content,increase hepatic catalase（CAT）,superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） activities,and improve liver total antioxidant capacity（T-AOC）.Conclusion： Tenebrio molitor oil can regulate blood lipid and enhance antioxidant function.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2011年第5期263-266,共4页
Food Science
关键词
黄粉虫油
高脂血症
血脂水平
抗氧化
Tenebrio molitor oil
hyperlipidemia
blood lipid
antioxidation
