摘要
目的研究喉癌组织中iNOS、eNOS的表达,探讨NOS与喉癌生物学行为的关系。方法采用免疫组化法检测60例喉鳞癌,3例喉腺癌中iNOS、eNOS的表达。结果 NOS的表达与喉癌病理类型、分化程度无关;iNOS及eNOS在喉癌Ⅱ～Ⅳ期中的表达明显高于Ⅰ期(P<0.05);在颈淋巴结转移组中的表达明显高于无颈淋巴结转移组(P<0.05)。结论 NOS对喉癌的生长、侵袭起促进作用,可作为预后的一项参考指标。
Purpose To investigate expression of nitrric oxide synthase (NOS) in laryngeal carcinoma and the relationship between the expression and the biological behaviors of laryngeal carcinoma. Methods The expression of iNOS and eNOS was examined by immunohistochemistry in 60 cases of squamous cell carcinoma and 3 cases of adenocarcinomas. Results The expressive rate of NOS had no association with histologic classification and differentiation degree of laryngeal carcinoma, respectively ( P > 0.05). The positive rate of NOS in laryngeal carcinoma in grade Ⅱ～Ⅳ was markedly higher than that in grade Ⅰ, ( P < 0.05) .The expressive rate of NOS in lymph node metastatic group was significantly higher than that in nonmetastatic group,(P < 0.05) . Conclusion NOS may promote the growth and invasion of laryngeal carcinoma. Its expression has relationship to prognosis of laryngeal neoplasm.
出处
《中国眼耳鼻喉科杂志》
2004年第3期146-147,共2页
Chinese Journal of Ophthalmology and Otorhinolaryngology
关键词
一氧化氮合酶
NOS
喉癌
生物学行为
病理类型
nitric oxide synthase
laryngeal neoplasm
carcinoma, squamous cell/adenocarcinoma
immunohistochemistry
