摘要
目的 调查肺炎克雷伯菌临床分离株近年来耐药谱的变迁。方法 菌株鉴定和药敏试验采用 VITEK- 32全自动微生物分析仪进行测定 ,超广谱β-内酰胺酶 (ESBL s)采用双纸片增效法 ,对近 5年来我院肺炎克雷伯菌的耐药谱进行回顾性调查。结果 肺炎克雷伯菌对青霉素类药物耐药率最高 ,氨苄西林高达 10 0 % ;对亚胺培南 /西司他丁的耐药率最低 ,除 1998年有 1株耐药外其余均为零 ;耐药率上升最快的是培氟沙星 ;氨基糖苷类和第三代头孢菌素药物具有较好的体外抗菌活性 ,产 ESBL s株稳定约在 2 0 %。结论 肺炎克雷伯菌临床分离株的耐药性日趋严重 ,氨基糖苷类、第三代头孢菌素及碳青酶烯类抗生素可用于控制肺炎克雷伯菌引起的感染。
OBJECTIVE To investigate the vicissitudes of the drug resistance pattern in the clinical isolates of Klebsiella pneumoniae during the past five years. METHODS The VITEK-32 automatic microorganism analysing system was used to identify the strains and their drug susceptibility. Double disk synergy test was adopted in the strains with extended spectrum β-lactamases (ESBLs). Retrospective studies were applied to analyze the drug resistance pattern of the clinical isolates of K. pneumoniae in our hospital. RESULTS As to K. pneumoniae ,the resistant ratio to penicillin was the highest,to ampicillin was up to 100%;the resistant ratio to imipenem was the lowest and there was only one strain resistant to imipenem in 1998;the rising rate of resistant ratio of pefloxacin was the fastest;the third generation cephalosporin and aminoglycosides showed good antibiotic activity in vitro . The ratios of the strains with ESBLs were around 20% stably. CONCLUSIONS The resistance of the clinical isolates of K. pneumoniae is severe gradually;aminoglycosides,third generation cephalosporin and imipenem could be used to control its infection.
出处
《中华医院感染学杂志》
CAS
CSCD
2004年第5期573-574,共2页
Chinese Journal of Nosocomiology
关键词
肺炎克雷伯菌
耐药性
监测
Klebsiella pneumoniae
Drug resistance
Monitoring
