摘要
目的 观察加味玉屏风散对被动吸烟大鼠肺组织损伤的影响。方法 以烟熏法制备被动吸烟大鼠模型 ,以病理切片法、生化分光光度等法分别观察加味玉屏风散对肺组织病理形态学、肺平均动脉压以及对肺组织中一氧化氮 (NO)含量、一氧化氮合酶 (NOS)活性、超氧化物歧化酶 (SOD)活性、丙二醛 (MDA)含量的影响。结果 加味玉屏风散可以明显改善模型大鼠的肺组织病理学改变 ,降低肺平均动脉压 ,并提高肺组织中NO含量、NOS活性、SOD活性以及降低MDA含量。结论 加味玉屏风散对被动吸烟大鼠所致肺损伤具有一定的保护作用。
AIM:To study the protective effects of JWYPFS on lung in jury caused by passive smoking in rats. METHODS: The model of passive smoking rat was caused by cigarette smoke. The influence of JWYPFS on pathomorphology of lung tissue, mean arterial pressure of lung, activity of NOS, SOD and content of No, MDA in lung tissue were observed. Results: JWYPFS obviously improved the pathomorphology of lung tissue, decreased the mean arterial pressure of lung, increased the content of NO, the activity of NOS and SOD, decreased the content of MDA in lung tissue. Conclusion:JWYPFS had the protective effects on lung in jury of rats caused by passive smoking.
出处
《中国实验方剂学杂志》
CAS
2004年第3期21-23,共3页
Chinese Journal of Experimental Traditional Medical Formulae
