摘要
采用阻抗血流图法研究了17名健康成人服用多烯康对缺氧性肺、脑血管反应性的影响。分别于服用多烯康前后测定肺、脑血管对缺氧（10％O2＋90％N2，5min）的反应性，以缺氧时阻抗图波幅变化的百分率表示。结果表明：服用多烯康1周后，缺氧性肺血管收缩反应（HPV）由（36．3±4．5）％减弱至（24．4±4．2）％，缺氧性脑血管扩张反应（HCD）[（－19．4±6．7）％）]则翻转为收缩反应[（2．5±4.0）％]（P＜0．05），服用2周后，HPV继降至（23．8±2．8）％（P＜0．05），缺氧时脑血管仍呈收缩反应[（11．9±3．0）％]（P＜0．01）；同时，基础脑阻抗血流图波幅由（34．9±3．3）m增为（39．9±2．7）m（P＜0．05），而基础肺阻抗血流日波幅不变。提示：多烯康可抑制人体缺氧性肺脑血管反应性，为临床缺氧性肺动脉高压和肺性脑病的防治提供了一定线索。
Effects of Duoxikang on hypoxic pulmonary and cerebral vasoreactivities were studied with impedance rheogram in 17 healthy adults (male 8, female 9). The impedance rheopneumogram and rheoencephanogram under normoxia and hypoxia (10 %O2+90% N2, 5min) were recorded be fore and after taking Duoxikang capsules for one week and two week respectively. The vasoreactivity was represented by the percentage of amlitude change in rheograms. The results showed that after one week application of Duoxikang,hypoxic pulmonary vasoconstriction (HPV) was inhibited from (36.3±4.5)% t0 (24.4±4.2)%, while hypoxic cerebrovascular dilation (HCD) [(-19.4±6.7)%] reversed to constriction t(2. 5±4.0)%] (P<0.05), one more week later, HPV was attenuated to (23. 8±2.8)% (P<0. 05), cerebrovascular reactivity to hypoxia also constrictive [11. 9±3.0)%] (P<0.01). At the same time, the baseline cerebral blood flow increased from (34. 9±3.3)m to (39.9±2.7) m (P<0. 05), while the pulmonary blood flow was unchanged.It suggested that Duoxikang can inhibit HPV and HCD, which will benefit the prevention and therapy of hypoxic pulmonary hypertension and pulmonary encephanopathy.
出处
《同济医科大学学报》
CSCD
1997年第5期336-339,共4页
Acta Universitatis Medicinae Tongji
基金
国家八五攻关项目!No.85-915-01-06
关键词
鱼油
缺氧症
肺循环
脑循环
多烯康
fish oil
hypoxemia
pulmonary circulation
cerebral circulation
