摘要
目的 评价慢性乙型病毒性肝炎 (CHB)患者血清转化生长因子 β1(TGF β1)测定的临床意义。 方法 采用酶联免疫吸附测定法测定 5 6例慢性乙型病毒性肝炎及肝硬化患者血清TGF β1水平 ,并检测肝功能、肝纤维化指标、门静脉及脾静脉内径 ;以健康人 2 0例为对照 ,并对患者组经 3个月的常规护肝治疗后比较其症状、肝功能、肝纤维化的改善程度。结果 随着患者病情的加重和肝纤维化的进展 ,血清TGF β1水平随之上升 ,即对照组 <慢性肝炎轻度 <慢性肝炎中度 <慢性肝炎重度 <肝硬化 (P <0 .0 1) ;患者组血清TGF β1与血清总胆红素 (TBIL)、透明质酸(HA)、层黏连蛋白 (LN)、Ⅲ型前胶原氨基端肽 (PⅢNP)、IV型胶原 (CIV)、脾门静脉内径呈正相关 (P <0 .0 1) ,与血清白蛋白 (ALB)呈负相关 (P <0 .0 1) ;经 3个月常规护肝治疗后 ,患者丙氨酸转氨酶 (ALT)、HA、PⅢNP改善程度与血清TGF β1呈负相关。 结论 TGF β1密切参与CHB肝细胞破坏和肝纤维化的病理过程 ,测定患者血清TGF β1可反映CHB患者肝细胞损害和肝纤维化程度 ,并能提示预后 ,对临床有较高的应用价值。
Objective To evaluate the clinical significance of determining the serum transforming growth factor beta-1(TGF-β1) in the patients with chronic viral hepatitis B(CHB).Methods Fifty-six patients with CHB and 20 healthy persons were selected.Their serum level of TGF-β1 was determined with enzyme linked immunosorbant assay.Their liver function,serum fibrosis markers,internal diameter of portal vein and portal vein of spleen,were also determined simultaneously.The patients were treated with regular project for 3 months,then their ameliorative level of liver function and fibrosis markers were determined.Results The serum level of TGF-β1 of patients with CHB was significantly higher than that of normal controls(P< 0.01) and increased significantly with developing of the disease.The order was normal control<mild<medium<severe<liver cirrhosis(P< 0.01).The serum level of TGF-β1 of patients was correlated with albumin(ALB) negatively and correlated positively with total bilirubin(TBIL),hyaluronic acid(HA),laminin(LN),N-terminal peptide of type Ⅲ procollagen(PⅢNP),type Ⅳ collagen(CⅣ) and internal diameter of portal vein of spleen.After 3 months of regular project for CHB,the serum level of TGF-β1 correlated with the ameliorative level of alanine aminotransferase(ALT),HA,PⅢNP negatively.Conclusion TGF-β1 was closely involved in the damage course of liver cells and liver cirrhosis of patients with CHB .The serum level of TGF-β1 reflects the level of liver function,the level of liver cirrhosis and the prognosis,which has a higher practical value.
出处
《临床荟萃》
CAS
北大核心
2004年第10期563-565,共3页
Clinical Focus
关键词
转化生长因子Β
肝炎
乙型
慢性
肝功能试验
肝硬化
预后
transforming growth factor beta
hepatitis B,chronic
liver function tests
liver cirrhosis
prognosis
