摘要
目的:探讨放射治疗对氨甲蝶呤血-脑屏障渗透吸收的促进情况。方法:利用放射对血-脑屏障的影响,静脉注射氨甲蝶呤(MTX)探讨脑部,照射前、中、后,MTX血-脑屏障渗透吸收变化。结果:放射线可降低血-脑屏障的作用,通过对17例脑肿瘤患者血药浓度的监测,可以看到脑脊液中MTX在照射前照射20Gy及40Gy后,浓度分别为(0.8±0.5)×10-8、(1.77±1.1)×10-8、(2±1.3)×10-8mol/L照射20Gy及40Gy后血-脑脊液屏障的通透性比照射前分别增加1.05和1.3倍(P<0.01,P<0.05)。结论:对脑瘤患者照射20Gy后,进行化疗,药效最佳。
OBJECTIVE: To study radiotherapy in promoting permeation and absorption of MTX by blood-brain barrier. METHODS: Since radiation had some effect on blood-brain barrier, so MTX was injected intravenously to study the changes of permeation and absorption of MTX by blood-brain barrier before, during and after irradiation. RESULTS: X-ray could decrease the effect of blood-brain barrier. By monitoring drug concentration of the blood in 17 patients with brain tumor, the concentration of MTX in cerebrospinal fluid before irradiation and after irradiating 20 Gy and 40Gy was (0.8±0.5)×10-8, (1.77±1.1 )×10-8 and (2 ± 1.3) ×10-8 mol/ L , respectively; Permeability of blood-cerebrospinal fluid barrier after irradiating 20Gy and 40Gy increased 1. 05 and 1.3 times (P < 0.01 , P < 0.05) than that before irradiation,respectively. CONCLUSION: The patients with brain tumor, who are carried out chemotherapy after irradiating 20Gy, will obtain best drug efficiency.
出处
《中国医院用药评价与分析》
2004年第1期36-38,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
