摘要
目的探讨脑胶质瘤术后应用BVD方案(卡氮芥+替尼泊甙+顺铂)静脉化疗的临床疗效.方法 35例Ⅲ～Ⅳ级脑胶质瘤患者,继手术及放疗后,采用卡氮芥(BCNU)125 mg,d1,2;替尼泊甙(VM-26)60 mg/m2,d3,4,5及d24,25,26;顺铂(DDP)30 mg/m2,d6,7,8及d27,28,29.6～8周为一周期,共3个周期.随访3年,观察复发率及毒副作用,并与同期及以前的43例脑胶质瘤患者(对照组)随访结果相对比.结果 BVD组的12,24,36个月的复发率分别为20.0%(7/35)、37.1%(13/35)和51.4%(18/35),明显低于对照组的25.6%(11/43)、53.5%(23/43)和74.4%(32/43),两组36个月复发率相比差异有显著性(P<0.05).结论脑胶质瘤术后、放疗后应用BVD方案静脉化疗可以提高远期疗效.
Objective To investigate the curative effect of intravenous chemotherapy with BVD （BCNU ＋ VM-26 ＋ DDP） in treating brain gliomas after surgical excision. Methods Thirty-five patients with brain gliomas （ grade Ⅲ -Ⅳ ） after surgical excision and radiotherapy were treated with BVD chemotherapy, The dosage of BCNU was 125 mg, d1,2;that of VM-26 was 60 mg/m^2, d 3,4,5 and d 24,25,26;that of DDP was 30 mg/m^2 ,d 6,7, 8 and d27,28,29. The therapy cycle comprised 6-8 weeks and 3 cycles were given altogether. The patients were followed up for three years, and were studied for recurrent rate and toxicity. The results were compared with 43 patients with brain gliomas who were treated at the same time or before （the control group） .Results At 12, 24, 36 months after treatment, the recurrent rate of group BVD was 20.0% （7/35）, 37.1% （13/35） and 51.4% （18/35） respectively, while that of the control group was 25.6 % （ 11/43 ）, 53.5 % （ 23/43 ） and 74.4 % （32/43） respectively. The recurrent rate of group BVD at 36 months was lower than that of the control group, with significant difference （ P 〈 0.05）. The toxicity in group BVD coald be tolerated. Conclusion The intravenous chemotherapy with BVD can improve the late curative effect of brain gliomas after surgical excision and radiotherapy.
出处
《中国肿瘤临床与康复》
2005年第4期319-321,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
