摘要
目的 :介绍碳青霉烯类抗生素进展及其临床评价。方法 :采用近期国内、外相关文献进行综述。结果与结论 :近年来 ,碳青霉烯抗生素进展十分迅速 ,其抗菌谱极广 ,杀菌活性超过头孢菌素 ,尤以对抗铜绿假单胞菌和耐甲氧西林金葡球菌的活性最为突出 ;其次 ,碳青霉烯类抗生素对细菌靶体蛋白、青霉素结合蛋白有良好的选择性毒性 ,已成为目前有关抗生素研究和开发的重要领域。
OBJECTIVE:To summarize the aspect of clinical evaluation and progress on carbapenem antibiotic.METHODS:To collect medical literatures in recent years at home and abroad. RESULTS & CONCLUSION:Advance in carbapenem antibiotic has been swiftly in recent years,it has a broad antibacterial spectrum against gram-positive and gram-negative bacteria and anaerobes. Antibacterial activity is stronger than that of cephalosporin ,especially the activities of pseudomonas and meticillin resistant staphylococcus aureus(MRSA) are the strongest.In addition,carbapenem antibiotic has good selective toxicity to target protein and penicillin- binding protein(PBP) of bacterium.It has now become an important field of antibiotic research and exploitation.
出处
《中国医院用药评价与分析》
2004年第2期71-75,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
碳青霉烯类
抗生素
抗感染作用
抗菌活性
抗菌谱
carbapenem antibiotic
antibacterial activity
progress
clinical evaluation
