摘要
目的 评价左氧氟沙星目前的耐药情况 ,并与其他药物做比较 ,为临床合理选药提供客观依据。方法 收集近 3年临床分离的细菌 ,包括 4 5 9株革兰氏阳性球菌及 76 7株肠道外的革兰氏阴性杆菌及 15 5 4株肠道致病菌。致病菌对抗生素的敏感性测定均采用 NCCL S推荐的 K- B法 ,应用 WHONET5软件进行药敏统计和分析。数据统计学处理采用 Stata软件。结果 左氧氟沙星对各种细菌的耐药率 :1对苯唑西林耐药葡萄球菌耐药率为 4 4 .5 % ,与 CPL X、CL DM相当 ,低于 PCG、EM、ST;2对苯唑西林敏感葡萄球菌 2 .6 % ,与糖肽类及头孢菌素类无差别 ,而低于 PCG、EM、ST及 CPL X;3对肠球菌 30 .0 % ,高于 VM、TEC,与 AMPC无差别 ,低于 PCG、EM及 CPL X;4对链球菌 10 .9% ,仅高于 VM,与 AMPC、CTX、TEC无差别 ,低于 PCG、EM、CL DM、ST;5对阴性菌的大肠埃希氏菌 4 7.0 % ,高于 IMP、CMZ、AMK、CPE、三代头孢菌素 ,AZ及CEZ,与 CPL X、GM相当 ,低于 AMPC、PIPC;6对肺炎克雷伯氏菌 10 .4 % ,高于 IMP、CAZ、CPE、AMK,而低于 AMPC,与其它抗生素无差别 ;7对气单胞菌无耐药 ,低于 CPZ/SB、AMPC、PIPC、CEZ、CMZ、IMP及CTX,与其它抗生素无差别 ;8对不动杆菌属 7.3% ,低于 AZ、AMPC、CEZ、CMZ,与其它抗生素无差别 ;9对ESBL
Objective To evaluate the levofloxacin resistance of bacteria and compare it to others antibiotics to provide the foundation for clinical treatment. Methods We collected 459 Gram positive isolates, 767 Gram negative isolates and 1554 enteric pathogenic bacteria come from the patients in our hospital recent 3 years. We tested the susceptibility of bacterium to antibiotics by K B methods. Statistic analysis with Whonet 5 and Stata software. Results The resistant rate of levofloxacin were as follows: ① MRS (44 5%) was similar to ciprofloxacin and clindamycin, lower than penicillin G, erythromycin, trimethoprim sulfamethoxazole; ② MSS (2 6%) was no difference to vancomycin and cephalosporin, but lower than penicillin G, erythromycin, trimethoprim sulfamethoxazole and ciprofloxacin; ③ Enterococcus (30 0%) was higher than vancomycin, teicoplanin, similar to ampicillin and lower than penicillin G, erythromycin and ciprofloxacin; ④ Streptococcus (10 9%) was only higher than vancomycin, parallel with ampicillin, cefotaxime, teicoplanin, lower than penicillin G, erythromycin, clindamycin, trimethoprim sulfamethoxazole; ⑤ Enter (47 0%) was higher than imipenem, cefmetazole, amikacin, cefepime, third generation cephalosporin, aztreonam and cefazolin, no difference to ciprofloxacin, gentamycin, lower than ampicillin, piperacillin; ⑥ Klebsiella genus (10 4%) was higher than imipenem, cefazolin, cefepime, amikacin, but lower than ampicillin; ⑦ Aeromonas spp. (0) was lower than cefoperazone/sulbactam, ampicillin, piperacillin, cefazolin, cefmetazole, imipenem and cefetaxime, no difference to others; ⑧ Acinetobacter spp. (7 3%) was lower than aztreonam, ampicillin, cefazolin, cefmetazole, no difference to others; ⑨ ESBL positive bacteria (58 3%) was higher than imipenem, cefepime, ceftazidime, amikacin, cefmetazole, cefoperazone/sulbactam, similar to third generation cephalosporin, aztreonam, ciprofloxacin; lower than ampicillin. Shigella flexneri was higher than third generation cephalosporin, Shigella sonnei, Vibrio and Salmonella are no difference to third generation cephalosporin, the others quinolones and fosfomycin, lower than ampicillin and trimethoprim sulfamethoxazole. Conclution Levofloxacin may be used as an empiric treatment for the infections due to pathogenic bacteria that included MSS, Enterococcus, Streptococcus, Klebsiella genus, Aeromonas spp., Acinetobacter spp. and enteric pathogenic bacteria from clinical sample.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2004年第5期316-319,共4页
Chinese Journal of Antibiotics
