摘要
目的 了解变形杆菌的耐药特征及耐药机制。方法 采用纸片扩散 (K B)法对变形杆菌作常规药敏 ,并用头孢他啶和头孢他啶 /克拉维酸 ;头孢噻肟和头孢噻肟 /克拉维酸以及亚胺培南、头孢吡肟对产超广谱β 内酰胺酶和头孢菌素酶 (AmpC酶 )进行筛选 ,用“WHONET5”软件对药敏结果进行分析处理。结果 对常用抗生素的耐药率 :青霉素G 1 0 0 % ,氨苄西林 2 5 % ,哌拉西林 2 .5 % ,头孢唑啉 1 5 % ,头孢呋辛 1 5 % ,头孢噻肟 0 % ,头孢曲松 0 % ,头孢吡肟 0 % ,氨曲南 0 % ,头孢西丁 0 % ,亚胺培南 0 % ,庆大霉素 2 0 % ,阿米卡星 0 % ,环丙沙星 1 5 % ,复方新诺明 4 7.5 % ,呋喃妥因 87.5 %。结论 青霉素、呋喃妥因、复方新诺明对变形杆菌耐药率高以外 ,其它 β 内酰胺类、氟喹诺酮类、氨基糖苷类对其显示较强的抗菌活性 。
Objective To study the resistant feature and its mechanism of the proteus.Methods Disc diffusion test(K B method) was used to study the antimicrobial resistance,and extended spectrum β Lactamases(ESBLs) and AMPCβ Lactamases were screened by ceftazidime and ceftazidime/clavulanate,cefetaxime and cefetaxime/ clavulanate,imipenem cefepime,and WHONET5 was applied for statistics analysis.Results The resistant rate of antibiotic was penicillin G 100%,ampicillin 25%,piperacillin 2.5% ,cefazolin 15%,cefuroxime 15%,cefetaxime 0,ceftriaxone 0,cefepime 0,azthreonam 0,cefoxitin 0,imipenem 0,garamycin 20%,amikacin 0,cinrofloxacin 15%,trimethoprim/sulfamethoxazole 47.5%,nitrofurantoin 87.5%.Conclusion The rate of resistance of penicillin,nitrofurantoin,trimethoprim/sulfamethoxazole,for proteus was higher,and the rate of resistance of the other β lactam antibiotics,quinolones,aminoglycoside was lower.They can be selected by clinic.
出处
《重庆医学》
CAS
CSCD
2003年第12期1644-1645,共2页
Chongqing medicine
