摘要
目的调查武汉地区临床分离菌对抗菌药物的耐药状况。方法收集１９９６年武汉地区１３所医院临床分离的致病菌，药敏试验采用ＫＢ法，用ＷＨＯＮＥＴ３计算机软件完成数据分析。结果１９９６年共收集致病菌４６３９株，包括革兰阳性球菌１３４５株（２９％），革兰阴性杆菌３２９４株（７１％）。致病菌以大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌、克雷白菌属最多见。１７％金黄色葡萄球菌和２５％凝固酶阴性葡萄球菌耐苯唑西林，也耐其他抗菌药物。亚胺培南、阿米卡星、头孢他啶、环丙沙星对革兰阴性杆菌（包括肠杆菌科细菌和非发酵菌）的抗菌作用最强。结论临床细菌耐药性日益严重，应在不同地区开展细菌耐药性监测。
Objective To study the antimicrobial resistance of clinical isolates in Wuhan area. Methods Bacterial susceptibility test was carried out by using Kirby Bauer method. A WHONET 3 computer software was used to analyse the results. Results Total of 4 639 clinical isolates, including 1 345 strains (29%) of Gram positive cocci and 3 294 stains (71%) of Gram negative bacilli were tested against 17 antimicrobial agents. E.coli, S.areus, P. aeruginosa and Klebsiella were the main microorganisms. 17% of S.aureus and 25% of the coagulase negative staphylococci (CNS) were resistant to oxacillin and other antimicrobials. Imipenem, amikacin, ceftazidime and ciprofloxacin were the most active agents anainst Gram negative organisms including Enterobacteriaceae and glucose nonfermenters. Conclusion It is suggested that there is an urgent need for surveillance of bacterial resistance in different districts and rational use of antimicrobial agents should be emphasised during clinical therapy.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1998年第7期440-443,共4页
Chinese Journal of Internal Medicine
基金
卫生部国际交流中心-默沙东科研基金
关键词
抗药性
微生物
武汉
Drug resistance, microbial Bacteria
