摘要
目的 研究 Ki- 6 7在喉良恶性肿瘤的表达情况及其与喉癌预后的关系。 方法 收集 33例喉良恶性肿瘤病理标本 ,标准链球菌卵白素标记生物素方法标记并记数 Ki- 6 7阳性表达细胞数 ,观察 Ki- 6 7在喉肿瘤的表达情况。 结果 Ki- 6 7在喉癌的表达明显高于良性肿瘤 ,差异有显著性 (P<0 .0 5 )。喉癌有淋巴结转移或复发的病例Ki- 6 7记数明显高于无转移或复发的病例 (P<0 .0 5 )。 结论 Ki- 6 7在喉癌的表达明显高于良性肿瘤 ,其表达水平与喉癌的增殖活性一致 。
Objective To study the expression of Ki-67 antigen in laryngeal neoplasm and try to detect the possible relationship between Ki-67 antigen and the prognosis of laryngeal carcinoma. {Methods} Total 33 cases of laryngeal neoplasm were included. Using immunohistochemistry LAB-SA staining method to mark the cellular nuclear, then counts the average number in three chosen high-power fields of hot-point in sections. Results The cellular nuclear was stained by Ki-67 antibody. The stained nuclear could be observed in most of benign and malignant tumor, but the level of count in malignant tumors was higher than benign ones(P<0 05). And also, the count in carcinoma with relapse or metastasis was higher than those without relapse or metastasis(P<0 05). Conclusion The high count of Ki-67 antigen correlated with laryngeal carcinoma and maybe an indication of metastasis or relapse of laryngeal carcinoma. Ki-67 antigen count in biopsy of laryngeal carcinoma before surgery will be beneficial to the choice of treatment and judgment of prognosis.;
出处
《福建医科大学学报》
2004年第2期166-168,F004,共4页
Journal of Fujian Medical University
