摘要
目的 :检测不稳定型心绞痛 (UAP)患者外周血中性粒细胞和单核巨噬细胞表面CD11b/CD18的表达 ,同时通过冠状动脉 (冠脉 )造影 (CAG)确定冠脉病变特点 ,以期探讨两者之间的关系以及UAP与白细胞活性的关系。方法 :正常对照组 16例 ,稳定型心绞痛 (SAP)组 14例 ,UAP组 4 5例 ,分别于CAG前采外周静脉血 ,以流式细胞仪测定中性粒细胞和单核巨噬细胞表面CD11b/CD18双阳性率表达程度 ;根据Braunwald心绞痛分级方法和定量CAG分析 (QCA)UAP患者的冠脉病变特点 ,分别将UAP组分成ⅠB、ⅡB、ⅢB级 ,并将病变长度、病变类型、病变累及血管数量和病变狭窄程度进行分析。结果 :UAP组外周血中性粒细胞和单核巨噬细胞表面的CD11b/CD18双阳性表达率明显高于正常对照组和SAP组 [(80 .4 9± 9.89) %∶(71.4 4± 14 .6 7) %和 (6 9.75± 18.6 8% ) ,均P <0 .0 1) ];ⅢB级UAP患者的CD11b/CD18双阳性表达率明显高于其他ⅠB、ⅡB级 [(91.78± 5 .6 7) %∶(77.82±9.6 5 ) % ,(76 .91± 8.15 ) % ,均P <0 .0 1) ];UAP组内长病变患者外周血黏附分子的阳性率虽高于非长病变患者 ,但差异无统计学意义 [(82 .0 2± 8.75 ) %∶(79.78± 9.6 4 ) % ,P >0 .0 5 ) ];从UAP组中不同病变类型可见 ,随着病变类型严重程度的加重 ,其炎性指标也?
Objective:To investigate expression of CD11b/CD18 antigen on the surface of neutrophil and mono- cytes in patients with unstable angina pectoris (UAP), and to analyze the characteristics of coronary arteries by coronary angiogram(CAG), then to discuss the relationship between UAP and activation of peripheral white blood cells.Methods:We examined the availability of CD11b/CD18 antigen in the plasma of 45 cases with UAP, 14 cases with stable angina pectoris(SAP) and 16 normal control subjects before CAG by flow-cytometry; UAP patients were divided into three groups of Ⅰ, Ⅱ, Ⅲ according to Braunwald classification, and coronary arteries lesions were analyzed by quantitative coronary analysis system.Results:Double CD11b/CD18 positive ratio of neutrophil and monocytes in UAP group was significantly higher than that in normal control subjects group and SAP group ( 80.49± 9.89)% vs ( 71.44± 14.67)% and ( 69.75± 18.68)%,P< 0.01); the value in UAP Ⅲ group was also higher than that in the other two groups ( 91.78± 5.67)% vs ( 77.82± 9.65)%,( 76.91± 8.15)%,P< 0.01). Of lesion >20 mm was higher than another group insignificantly ( 82.02± 8.75)% vs ( 79.78± 9.64)%,P> 0.05). In other subgroups, we found that there was not significant relationship between CD11b/CD18 double. Conclusion:Neutrophil and monocytes in peripheral blood are activated in the patients with UAP. Inflammation reaction is related to the instability of plaque.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2004年第4期207-209,共3页
Journal of Clinical Cardiology
关键词
心绞痛
不稳定型
细胞黏附分子
冠状动脉造影
Unstable angina pectoris
Cell adhesion molecule
Coronary angiography
