摘要
目的 探讨β受体-腺苷酸环化酶系统对心肌梗死后心室重构的影响及中药通心络对心室重构的干预作用。方法 制备大鼠心肌梗死后心室重构模型,随机分成心室重构组、通心络治疗组、假手术组,6周后分别测定血流动力学参数、β受体密度、cAMP含量,电镜观察其超微结构的变化。结果(1)与假手术组比较,心室重构组及通心络组的血压降低,左室舒张末压(LVEDP)升高(P<O.05)。与心室重构组相比,通心络组收缩压(SBP)、左室收缩压(LVSP)、+dp/dt_(max)、-dp/dt_(max)明显升高(P<0.05)。(2)与假手术组比较,心室重构组及通心络组β受体密度和cAMP含量均降低,而通心络组较心室重构组β受体密度及cAMP,含量均高(P<O.05)。(3)电镜下心室重构组间质纤维母细胞增生明显,呈高合成状态,间质胶原蛋白沉着明显,见典型的间质胶原纤维沉积。通心络组上述病理改变程度较轻。结论 通心络可在一定程度上抑制心肌梗死后大鼠的心室重构。
Objective To study the influence of β- adrenoreceptor pathway on ventricular remodeling of rats with heart failure and the regulative effect of Tongxinluo on it. Methods Rat model with ventricular remodeling was made by the way of myocardial infarction. Six weeks later, the parameter of hemodynamics was determined,β - adren-ergic receptor density(Bmax )and the content of cAMP were measured, and the changes of the ultrastructure were observed as well.Results In comparation with false operation group,the blood pressure,(β-adrenergic receptor density and content of c AMP was reduced in ventricular remodeling group and Tongxinluo group, but LVEDP was raised. SBP, LVSP, + dp/dtmax, - dp/dtmax ,(3 - adrenergic receptor density and content of cAMP were increased more significanthy in Tongxinluo group than in ventricular remodeling group ( P < 0.05) . The fibroblast proliferation, collagen sludge and collagen fiber deposit were found by electron microscopy on intersexuality of rats in ventricular remodeling. These pathologic changes were more slight in Tongxinluo group than in ventricular remodeling group. Conclusion Tongxinluo can improve the cardiac function of rats with ventricular remodeling, increase myocardium Bmax the contents of c AMP, and relieve the myocardium pathologic lesion caused by remodeling in the rats. Tongxinluo could partially depress the ventricular remodeling of rats with heart failure after myocardial infarction.
出处
《疑难病杂志》
CAS
2002年第1期12-14,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
心力衰竭/中医药疗法
心室重构
心肌梗死
通心络
Heart failure
Therapy of TCM
Ventricular remodeling
myocardial infarction
Tongxinluo
