摘要
目的 探讨 2型糖尿病 (T2DM)合并急性脑梗死 (ACl)患者超早期的血液流变学及血脂变化。方法 回顾性统计5 6例T2DM患者 (其中合并ACI者 2 0例 ,无ACI者 36例 )的血脂、空腹血糖 (FBG)及血液流变学检测结果。结果 T2DM并ACI组TC、LDL -C、TC及FBG明显高于无ACI组、正常对照组 (P <0 0 1)。T2DM并ACI组和无ACI组全血粘度高切、低切、还原粘度、血浆粘度、RBC电泳时间、纤维蛋白原明显高于正常对照组 (P <0 0 1) ,而ACI组全血粘度高切、低切、还原粘度及血浆粘度、RBC电泳时间高于无ACI组 (P <0 0 5 )。调整年龄、病程并再分别调整血糖、血脂计算血液流变学各指标与血脂、血糖之间的偏相关系数 ,结果显示血浆粘度与TC、TG呈正相关 (r =0 389、0 347,P =0 0 0 4、0 0 11) ;FBG与高切、低切、RBC电泳时间呈正相关 (r =0 380、0 35 8、0 381,P =0 0 0 6、0 0 1、0 0 0 6 ) ,而与血沉呈负相关 (r =- 0 394 ,P =0 0 0 4 )。回归分析结果显示血浆粘度、LDL -C、TG、FBG是糖尿病合并脑梗死的危险因素。结论 T2DM在发生ACI早期就已存在血脂、血糖及血液流变学异常 ,血液流变学改变可能为T2DM和脑梗死的共同病理生理基础 ,因此有效的控制血脂、血糖 ,纠正糖脂代谢紊乱 ,改善血液流变学状态 ,是预?
Objective To investigate the changes of blood rheology and blood-lipid in patients with type 2 diabetes mellitus (T2DM) complicated by super early acute cerebral infarction(ACI).Methods Blood-lipid,fasting blood glucose (FBG) and blood rheology were retrospectively studied in 56 T2DM patients(20 with ACI and 36 without ACI).Results TC,LDL-C,TC and FBG in T2DM patients with ACI were significantly higher than that in T2DM patients without ACI and in control group (P<0.01).The whole blood viscosity (higher and lower),reducing viscosity,plasma viscosity and erythrocyte electrophoresis time in T2DM patients with AIC were higher than that in T2DM patients without AIC (P<0.05).There was significant correlation between plasma viscosity and TC,TG (r=0.389、0.347,P=0.004、0.01),the same correlation existed between FBG and the whole blood viscosity,erythrocyte electrophoresis time (r=0.380,0.358,0.381,P=0.006,0.01,0.006),The result of the regression analysis showed that plasma viscosity,LDL-C,TG,FBG were the dangerous factors of T2DM with ACI.Conclusion There was marked elevation in blood-lipid,blood rheology and FBG in T2DM patients with ACI.The control of blood lipid,blood glucose and blood rheolgy is important for prevention of ACI in T2DM patients.
出处
《广西医学》
CAS
2004年第4期492-495,共4页
Guangxi Medical Journal
