摘要
目的 :探讨原发性肝细胞癌 (hepato cellularcarcinoma ,HCC )的细胞免疫学状态及其与预后的相关性。方法 :应用流式细胞仪和ELISA方法测定 3 5例HCC患者和 2 0位正常献血员的CD+3 、CD+4、CD+8、CD+4/CD+8、NK细胞和AFP。结果 :1)HCC患者CD+3 、CD+4、CD+4/CD+8、NK细胞活性明显低于正常人 ,P <0 0 1,CD+8高于正常人 ,P <0 0 5 ;2 ) 3 5例中伴有门静脉癌栓或肝内转移者 10例 ,T细胞亚群及NK细胞活性明显低于不伴有门静脉癌栓者 2 5例 ,P <0 0 5 ;3 )机体的细胞免疫学状态与AFP无明显相关性。结论 :HCC患者的细胞免疫功能处于抑制状态 ,且与肿瘤细胞的侵袭活性有关。
OBJECTIVES:To study the cell immune status in hepatocellular carcinoma (HCC),and to investigate the correlation of this and prognosis.METHODS:T cell subsets (CD + 3,CD + 4,CD + 8),NK and AFP of HCC (35 cases) and control group (20 cases) were determined with flow cytometry and ELISA.RESULTS:1) CD + 3,CD + 4,CD + 4/CD + 8,NK of patients with HCC were much lower than those of control group, P <0 05;2) In 35 cases,there were 10 cases with portal cancer embolus or metastasis in liver,and the T cell subsets and NK were much lower in them than those in other 25 cases without portal cancer embolus, P <0 05;3)In correlative analysis there was no significance between T cell subsets and the level of AFP.CONCLUSIONS:The condition of cellular immunity of the patients with HCC is worse than that of normal persons,and it has the correlation with the invasive activity of tumor cell.
出处
《肿瘤防治杂志》
2004年第2期127-130,共4页
China Journal of Cancer Prevention and Treatment
关键词
肝肿瘤/免疫学
T淋巴细胞亚群
预后
liver neoplasms/immunology
T lymphocyte subsets
prognosis
