摘要
研究肝癌组织内Ⅰ、Ⅲ型胶原与患者预后的关系。应用免疫组化方法对60例肝细胞癌组织作Ⅰ、Ⅲ型胶原定位和半定量分析。结果：患者5年生存率在癌内Ⅰ、Ⅲ型胶原染色强阳性组中明显高于中等阳性和弱阳性组（P＜0．05）；在出现癌栓的病例中，Ⅰ、Ⅲ型胶原强阳性和中等阳性组的例数明显少于无癌栓组（P＜0.05）；并观察到肝癌细胞胞质内Ⅰ、Ⅲ型胶原染色阳性。结论：Ⅰ、Ⅲ型胶原可作为肝癌预后判断的一个指征；癌内胶原主要来自间质细胞，但肝癌细胞有合成胶原的可能。
PURPOSE TO investigate the significance of the collagen type Ⅰ and type Ⅲ within the cancerous tissue,and the relationship between the collagens and the prognosis in human hepatocellular carcinoma(HCC).METHODS Collagen type Ⅰ and type Ⅲ were immunohistochemically localized and half-quantitated in60 HCC cases.RESULTS The 5 years survival rate of in the strong Positive cases of collagen type Ⅰ and type Ⅲ wasmarkedly higher than that in the moderately and weakly positive cases (P< 0. 05). In the cases with carcinousembolis, the number of the strong and moderately positive cases of collagen type Ⅰ and type Ⅲ was obviouslyfewer than that in the cases without carcinous embelis (P < 0. 05). Besides the interstitum, positive staining ofcollagen type Ⅰ and type Ⅲ was also found in the cytoplasm of HCC cells in one case.CONCLUSIONS Collagen type Ⅰ and type Ⅲ within the cancerous tissue may be used as a indicator forevaluation of prognosis of patients with HCC. The tumor cell of HCC may take part in the formation of collagensin cancerous lesion. However, the interstital cells are the main sourse of collagen producing.
出处
《上海医科大学学报》
CSCD
1997年第5期347-350,共4页
Journal of Fudan University(Medical Science)
基金
美国中华医学基金!95838
国家自然科学基金!3933014
关键词
肝细胞癌
Ⅰ型胶原
Ⅲ型胶原
预后
肝肿瘤
hepatocellular carcinoma
type Ⅰ collagen
type Ⅲ collagen
prognosis
