摘要
本文研究黄磷与CCl_4引起亚急性肝损害时,肝脏发生脂质过氧化的情况、部位及其与肝损害之间的关系。黄磷与CCl_4对大鼠亚急性中毒时,肝MDA 含量显著升高,Schiff 碱荧光强度明显增强;肝线粒体与微粒体MDA含量显著升高,且各自标志酶SDHase 活性与G-6-Pase 活性均显著降低;肝损害指标:肝TG 含量升高对两种毒物均敏感;而肝GSH 含量降低与血清SGPT 酶活性升高对两种毒物的敏感性有一定的差异。
Subacute liver injury induced by phosphorus and CCl_4 by interfering lipidperoxidation was studied.In poisoned rats,the content of hepatic MDA wasfound to be significantly increased,as shown by an increase in fluorescent in-tensity of Schiff base in the liver.MDA was also increased in hepaticmitochondria and microsome,while the activities of SDHase and G-6-Pasewere significantly lowered.Liver injury indices caused by the two poisons re-vealed that hepatic TG level increases with same sensitivity,but hepatic GSHlowered and serum SGPT activity increased with different degree of sensitivity.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1992年第4期202-204,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
黄磷
四氯化碳
肝损害
Lipid peroxidation
Free radical
Liver injury
Phosphorus
Carbon tetrachloride
