摘要
研究观察了经腹腔注射黄磷（ 每次１－５ ｍｇ／ｋｇ ｂ－ｗ ．， 每周三次） 的亚急性染毒大鼠１ 周， ２ 周， ３ 周三个不同时点肝脏的超氧化物歧化酶、谷胱甘肽过氧化物酶等抗氧化酶活力及脂质过氧化物—丙二醛含量的变化关系。结果表明，黄磷亚急性染毒组肝脏中上述的抗氧化酶活性于所设三个时点中的２ 周及３ 周均比对照组低（ Ｐ＜ ０－０１） ，同时丙二醛含量高于对照组（ Ｐ＜ ０－０１） 。提示，黄磷亚急性染毒大鼠中肝脏抗氧化酶活性受黄磷毒性所抑制， 出现肝脏脂质过氧化并造成肝损害。同时， 结果也表明黄磷亚急性染毒大鼠血清中丙二醛含量与肝脏丙二醛含量存在着高度密切的正相关关系（ Ｐ＜ ０－０１） ， 且前者升高的时间比血清谷丙转氨酶升高早。提示， 血清丙二醛可能可以作为黄磷亚急性染毒对肝脏损害较敏感的指标。
Both blood and liver of rats were collected at the 1st, 2nd and the 3rd week after i-p .administration of yellow phosphorus (1-5 mg/kg boby weight) . The activities of superoxidedismutase (SOD) and glutathione peroxidase (GSH- Px) , and thelevelof malondialdehyde( MDA) wereinvestigated inliver homogenateofrats. Moreover, thelevelof MDAin ratserum wasalsoin vestigated. The resultsshowed that the activities of SODand GSH- Px in liver of rats acutely ex posed to yellow phosphorus wassignificantlylowerthan those of the control ( P< 0-01) at the 2ndand 3rd week , meanwhile,thelevelof MDAin the former was higher than that ofthelatter when treated with yellow phosphorus.It suggested that yellow phosphorus could inhibit the activities ofSODand GSH- Px , and inducelipid peroxidation in theliver of rats. The result also revealed that the serum MDAlevelin rats exposed to yellow phosphorus was positively correlated with that ofliverofthe same group ( P< 0-01) . The MDAlevelofserum might bethe moresensitiveindex than the activity of GPTin serum in predicting theliver damage caused by yellow phosphorus.
出处
《工业卫生与职业病》
CAS
CSCD
1999年第5期285-287,共3页
Industrial Health and Occupational Diseases
关键词
黄磷
亚急性染毒大鼠
丙二醛
SOD
GSH-PX
Yellow phosphorus subacute poisoning Malondialdehyde ( MDA) Superoxidedismutase (SOD) Glutathione peroxidase (GSH- Px)
