摘要
谷氨酸锌溶液剂给兔口服后的药物动力学符合二室模型:k_a=1.25 h^(-1),α=0.64 h^(-1),β=0.37h^(-1),T_(max)=2.85 h,C_(max)=6.43μg/ml。谷氨酸锌溶液的相对生物利用度为66%。谷氨酸锌溶液、硫酸锌溶液和葡萄糖酸锌糖浆药物动力学的比较表明,谷氨酸锌为一种较好的补锌剂。
The pharmacokinetics of zinc glutamate solution(1)administered
p.o.in rabbits was in accordance with two-compartment model:k_a=1.25h^(-1),α=
0.64h^(-1),β=0.37h^(-1),T_(max)=2.85h,C_(max)=6.43μg/ml.Its relative bioavailability was
66%.The pharmacokinetics of 1,zinc sulfate solution and zinc gluconate syrup
were compared.The results showed that 1 was a better zinc-supplementary drug.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1992年第3期114-116,共3页
Chinese Journal of Pharmaceuticals
关键词
谷氨酸锌
溶液剂
药物动力学
zinc glutamate
solution
relative bioavailability
pharmacokinetics
