摘要
本文选择 N-甲基-2-吡咯烷酮及尿素为渗透促进剂,经正交试验组合处方制备了布洛芬软膏。用小鼠皮代替半透膜做各软膏的体外透皮释放率测定,结果最佳组方软膏的7.5h 累积释放率可达46.94%,其镇痛、消炎作用的药效学试验均获得较好结果。提示该透皮给药系统在体内已达到有效血药浓度。
Ibuprofen ointment was prepared with N-methyl-2-pyrrolidone and urea which acted as pene-trative accelerants.Its composition was designed byusing the method of orthogonal test.The percuta-neous release rate of the ibuprofen ointment was de-termined in vitro with the mouse's skin instead ofcellophane membrane.The results showed that accu-mulative release rate was 46.94% in 7.5 hours.The analgesic and antiphlogistic effects determinedpharmacodynamically were satisfactory.It suggeststhat the effective blood concentration of ibuprofenhas been reached.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1992年第6期346-347,共2页
Chinese Pharmaceutical Journal
关键词
布洛芬软膏
透皮释放率
尿素
ibuprofen ointment
percutaneous release rate
N-methyl-2-myrrolidone
urea
