摘要
阿西美辛胶囊剂对10名健康志愿受试者进行了体内相对生物利用度试验研究。本试验采用阿西美辛胶囊剂与阿西美辛混悬剂,通过随机交叉试验设计单剂量(90mg/人)口服法用 HPLC 测其血药浓度,并用 PKBP-N_1程序求算药物动力学参数,提取两剂型 AUC_(0～∞),C_(max),T_(max)三参数作方差分析。结果证明,阿西美辛胶囊剂与阿西美辛混悬剂具生物等效(P>0.05)。
The bioavailability of acemetacin capsules and acemetacin suspension were compared in 10 healthy male and female volunteers after oraladministration of single dose of 90 mg.Doseswere given randomly after 12 hours fast serumlevels of both compounds were determined byHPLC procedures.Both drugs were absorbedslowly,with a mean peak serum level of 1.49 μg·ml^(-1)at 2.72h(cap.)and 1.48 μg.ml^(-1)at2.79h(sus.).Elimination half-life ofacemetacin capsules and suspension was 2.62±0.16h and 2.92±0.84h,respectively.Thearea under the acemetacin capsules serum curvewas similar(P>0.05).Serum data indicatedthat both preparations were equally well ab-sorbed.The bioavailability of the acemetacincapsules and the acemetacin suspension wereproved equally by both preparations in humanbody test.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1992年第3期148-150,共3页
Chinese Pharmaceutical Journal
关键词
阿西美辛
胶囊
混悬剂
利用度
acemetacin capsules
acemetacin suspension
relative bioavailability
HPLC
