摘要
目的:制备阿西美辛果胶铋凝胶微丸,考察果胶铋凝胶微丸的溶胀及释药性质。方法:采用滴制法制备阿西美辛果胶铋凝胶微丸,考察其在不同介质中的溶胀特性,并考察果胶浓度,铋离子浓度,投药量对药物释放影响。结果:果胶铋凝胶微丸的溶胀具有pH依赖性。果胶浓度,铋离子浓度,投药量增加,药物释放速率有所减慢。结论:阿西美辛果胶铋凝胶微丸具有良好的缓释作用,有望成为一种新型的药物缓释载体。
OBJECTIVE To prepare acemetacinqoaded bismuth pectin gel beads and investigate swelling degree and release properties. METHODS Acemetacin-loaded bismuth pectin gel beads were prepared by dropping method. Swelling properties were investigated,and the effects of several factors such as the concentration of pectin and bismuth ion, drug loading on drug release were studied. RESULTS Swelling properties of bismuth pectin gel beads were pH-dependence. Increasing the concentration of pectin or bismuth ion,drug loading, the rate of drug release decreased. CONCLUSION Acemetacin-loaded bismuth pectin gel beads show good sustained-release properties, which are potential drugs vehicle.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2010年第19期1630-1634,共5页
Chinese Journal of Hospital Pharmacy
基金
重庆市科委自然科学基金项目(编号:CSTC
2008BB5397)
重庆医科大学校办课题项目(编号:XBYB2007098
NSFYY200728)
关键词
果胶铋
阿西美辛
凝胶微丸
缓释制剂
bismuth pectin
acemetacin
gel beads
sustained-release
