摘要
iv10～20mg/kg(木解)皮素磷酸酯钾使兔急性心肌梗塞范围明显缩小,ST段明显降低,并能对抗冠脉结扎后引起的血清CPK含量增加及心律失常,这些作用与普萘洛尔相似。但iv40mg/kg后作用不明显。
Potassium quercetin phosphate ( PQP, iv 10~20mg/kg ) significantly decreased the size of infarction and S-T segment elevation induced by coronary artery ligation in rabbits (P<0.05), meanwhile PQP could reduce the plasma CPK activity and ventricular arrhythmias induced by coronary artery ligation (P<0.05). These effects are similar to those of propranolol. But PQP (iv 40mg/kg) couldn't obviously influence them. The above results suggeste that PQP ( iv 10~20mg/kg ) is beneficial and safe in limitation of EMI size and antiarrhythmia.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第1期69-72,共4页
Chinese Pharmacological Bulletin
关键词
槲皮素
磷酸酯钾
心肌梗塞
Potassium quercetin phosphate ( PQP ): Experimental myocardial infarction ( EMI )
Creatine phosphokinase
Propranolol
