摘要
用四动脉结扎法造成大鼠急性全脑缺血．４５ｍｉｎ缺血后再灌１ｈ造成再灌损伤模型。槲皮素磷酸酯钾在缺血前５ｍｉｎ及再灌前５ｍｉｎ各静注一次（２０ｍｇ·ｋｇ－１）·可减轻脑水肿并缓解脑损伤时ＣＫ的释放．保护ＳＯＤ的活性及降低脑组织ＭＤＡ的升高。提示槲皮素磷酸酯钾对脑缺血再灌损伤有保护作用。此作用可能与保护ＳＯＤ活性．抑制自由基的产生或直接清除自由基有关。
The reperfusion injuries were performed by 45 min four-vessel occlusion and 1hsubsequent release in rats.Potassium quercetinphosphate(PQP),20 mg·kg-1 iv 5 min beforecomplete ischemia and the second one 5 min before release,declined brain edema formation(P<0.01),reduced the rise of lipid peroxidase(P<0.05),and suppressed the reduction in bothcreatine phosphokinase(CK)(P<0.01)andsuperoxide dismutase(SOD)activity( P <0.01)in brain tissue.The results suggest thatthe mechanism of the protective effects of PQPbe associated with the inhibition of the generation of oxygen free radicals, with the preventionof inactivation of SOD and(or) with the directscavenging of oxygen free radicals in tissues.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1994年第3期204-206,共3页
Chinese Pharmacological Bulletin
关键词
磷酸酯钾
脑缺血
再灌注损伤
potassium quercetin phosphate(PQP)
transient cerebral ischemia
reperfusioninjury
lipid peroxidase
superoxide dismutase(SOD)
free radicals
brain edema
