4Multhaup G,Thamas R,Andrea S, et al. Reactive oxygen species and Alzheimer' s disease [ J ]. Biochemical Pharmacology, 1997,54 : 533.
5Mantyh PW, Ghilardi JR, Rogers S, et al. Aluminum, iron and zinc ions promote aggregation of physiological concentrations of β - amyloid peptide[ J]. J Neurochem, 1993,61 :1171.
6Bondy SC , Guo Ross SX , Truong AT, et al. Promotion of transition metal- induced reactive oxygen species formation by β- amyloid [J]. Brain Research , 1998,799:91.
7Atwood CS , Moir RD, Xudong Huang, et al. Dramatic Aggregation of Alzheimer Aβ by Cu(Ⅱ) Is Induced by Conditions Representing Physiological Acidosis[ J]. The Journal of Biological Chemistry , 1998,273(21) : 12817.
8Huang X, Atwood CS, Hartshorn MA, et al.The amyloid-β - peptide of Alzheimer' s disease directly produces hydrogenperoxide through metal ion reduction [ J ]. Biochemistry ,1999,3:7609.
9Behl c , Davis JB, Lesley R, et al. Hydrogenperoxide mediates amyloid beta protein toxicity[J]. Cell, 1994,77(6) :817.
10Calderon FH , Bonnefont A , Munoz FJ , et al. PC12 andneuro 2a ceils have different susceptibilities to acetylcholinesterase- amyloid complexes, amyloid 25 - 35 fragment, glutamate, and hydrogen peroxide [ J ] . Journal of Neuroscience Research, 1999,56(6) :620.
8Kourie JI.Mechanisms of amyloid beta protein induced modification in ion transport systems:implications for neurodegenerative diseases cell moi.Neurobiol.2001,21:173.
9Arispe N,Poilard HB,Rojas E.Ciant multilevel cation channels fonded by Alzheimer's disease amyloid beta-protein (1-40) in bilayer membranes.Proc.Nati Acad Sci USA.1993,90(22):10573.
