摘要
目的 :探讨膀胱移行细胞癌 (BTCC)中的细胞凋亡指数与膀胱癌发生、发展的关系。方法 :用缺口末端标记法(TUNEL)检测 12例正常膀胱粘膜和 4 3例BTCC中的凋亡细胞指数。结果 :BTCC中的AI高于正常膀胱粘膜中的AI(P<0 0 1) ;AI随病理分级的增高而降低 ,各级之间差异有显著性 (F =4 1 14 2 ,P <0 0 1) ;AI在Tis-T1 期高于T2 ～T4期 (P<0 0 5) ;AI在无复发组高于复发组 (P <0 0 1)。结论 :凋亡指数随病理分级和临床分期升高而降低 。
Objective: To investigate the apoptosis of bladder transition al cell carcinoma(BTCC) and the relation between the apoptosis and the progression of BTCC Methods: The apoptosis cells index(AI) were detected by the ter minal deoxynucleotidyl transferase-mediated d-UTP nick end labeling(TUNEL) in 43 BTCC specimens and 12 normal bladder mucosa tissues Results: T he AI in normal bladder mucosa group was significantly lower than that in BTCC ( P<0 01) The higher the tumor grade was, the lower the AI would be, and t h ere was significant differene among tumors at different grades (F=41 142, P <0 01) The AI in Tis-T 1 stage was significantly higher than that in T 2 - T 4 stage (P<0 05) The AI in recurrence group was significantly lower t ha n that in group without recurrence (P<0 01) Conclusions: T he higher the tumor grade of histological differentiation is and the later the cli nical stage of BTCC showes, the lower the AI will be The decrease of apoptosis might be one of the reasons causing progression of BTCC
出处
《宁夏医学院学报》
2004年第1期22-23,共2页
Journal of Ningxia Medical College
