摘要
目的:探讨缺血性脑梗死患者不同病变时期血中C反应蛋白、纤维蛋白原、神经元特异性烯醇酶(NSE)的变化与缺血性脑卒中关系。方法:临床确诊缺血性脑卒中患者69例,分别检测缺血性脑卒中患者不同病变时期的C反应蛋白、纤维蛋白原、NSE的浓度,选择20例门诊健康体检者作为正常对照组。结果:缺血性脑卒中患者的C反应蛋白:急性期为(17.28±3.82)mg/L;亚急性期为(11.55±1.95)mg/L;恢复期为(7.10±1.30)mg/L。与正常值(4.65±1.39)mg/L相比差异均有显著意义(t=12.717～2.5382,P<0.05或0.01)。纤维蛋白原急性期,亚急性期和恢复期分别为(4.62±0.61),(4.09±0.62),(3.21±0.65)mg/L,与正常值(2.26±0.22)mg/L比差异有显著性意义(t=2.3602～1.8244,P均<0.01)。NSE急性期是(22.27±5.69)mg/L;亚急性期是(13.62±2.74)mg/L;恢复期为(9.16±1.44)mg/L,与正常组(3.08±1.51)mg/L比较差异也均有显著性意义(t=19.1844～6.0735,P<0.01)。随着病程的发展,从急性期到亚急性期以及恢复期,C反应蛋白、纤维蛋白原、NSE的浓度均有明显的下降(F=12.042～3.322,P<0.05)。结论:随着病情的进展,C反应蛋白、纤维蛋白原、NSE存在着动态变化,病情好转,三者的浓度明显下降,呈正相关。
AIM:To observe the changes of the contents of C reactive protein(CRP),neuron specific enolase(NSE) and fibrinogen(FIB) in the patients with ischemic stroke,and to investigate their relation with ischemic stroke. METHODS:The contents of CRP NSE and FIB at different lesion stage were measured in 69 patients with finial diagnosis of ischemic stroke in clinic and 20 healthy controls. RESULTS:In the patients with ischemic stroke, the content of CRP was(17.28±3.82) mg/L at acute stage,(11.55±1.95) mg/L at subacute stage and(7.10±1.30) mg/L at recovery stage, significantly different from that in the control group[(1.65±1.39) mg/L]respectively (t=12.717-2.5382,P< 0.05 or 0.01);the contents of FIB were(4.62±0.61),( 4.09±0.62) and( 3.21±0.65) mg/L respectively,with significant difference from that in the control group[(2.26±0.22) mg/L](t=2.360 2-1.824 4,P< 0.01);the contents of NSE were(22.27±5.69),(13.62±2.74) and( 9.16±1.44) mg/L respectively, also with significant difference from that in the control group[(3.08±1.51) mg/L](t=19.184 4-6.073 5,P< 0.01).The contents of CRP, FIB and NSE were all decreased significantly from acute stage to recovery stage(F=12.042-3.322,P< 0.05). CONCLUSION:With the development of disease,dynamic chages esxist in the comtents of CRP,FIB and NSE,and the obvious decrease of them is positively correlated with the improvement of disease.
出处
《中国临床康复》
CAS
CSCD
2004年第10期1884-1885,共2页
Chinese Journal of Clinical Rehabilitation
