摘要
目的:探讨急性缺血性脑卒中患者急性期血清C反应蛋白(C-reactiveprotein,CRP)水平与疾病预后的相关性。方法:选取住院确诊为急性缺血性脑卒中患者,根据入院时血清CRP水平分为CRP正常组(CRP≤10mg/L)及CRP增高组(CRP>10mg/L),再根据患者性别、年龄、危险因子及入院时神经功能缺损程度评分值进行配对,共选择有效病例23对,血清CRP含量于发病48h内进行测定,并应用改良爱丁堡-斯堪的那维亚评分法(modifiedEdin-burgh-Scandinavianscoringscale,MESSS)分别于入院当时、1周、1,3个月对患者进行神经功能缺损评分;血清CRP应用TurboxR特定蛋白分析系统以散射比浊法测定。结果:急性缺血性脑卒中组患者血清CRP水平明显增高,且CRP正常组(6.99±1.90)mg/L及CRP增高组(14.79±4.68)mg/L与正常对照组(5.24±1.91)mg/L相比,差别有显著性意义(分别为t=2.541,P=0.019和t=7.734,P<0.001)。入院时神经功能缺损评分,CRP正常组(17±8)及CRP增高组(18±7)相比差异无显著性意义(z=0.020,P=0.984),治疗1周及1个月后,CRP正常组分值分别为12±7、10±6,CRP增高组为14±7,12±7,两组相比差异具有显著性意义(分别z=2.037,P=0.042及z=2.319,P=0.020),3个月后,CRP正常组神经功能缺损分值(8±5)较CRP增高组(11±7)下降程度更明显(z=2.681,
AIM:To explore the relationship between the level of serum C-reactive protein (CRP) at acute period of ischemic stroke and the prognosis of the disease. METHODS:Forty-six inpatients with acute ischemic stroke were selected and pai red according to their CRP levels measured within 48 h after the onset, their ag e, sex, risk factors including smoking, alcohol misuse, history of diabetes mell itus, hypertension and hypertriglyceride and the score of neurologic impairment when the patients were of hospitalization. They were divided into CRP normal gro up(CRP≤10 mg/L)and CRP increased group(CRP >10 mg/L). The modified Edinburg h-Scandinavian scoring scale (MESSS) was used to determine their score of neuro logic impairment at 1 d, 1 week, 1 month and 3 months after admission respective ly.CRP levels were measured by scatter turbidimetry with TurboxR special protein analysis system. Other forty-six normal subjects were chosed as control group. RESULTS:The levels of serum CRP in acute ischemic stroke patients increased si gnificantly in both CRP normal group[(6.99±1.90)mg/L] and CRP increased group [(14.79±4.68)mg/L] as compared with the control group[(5.24±1.91)mg/L](t=2.5 41,P=0.019;t=7.734,P=0.000 respectively).The score of neurologic impairment in CRP normal group (17±8)was similar as that in CRP increased group (18±7)w hen the patients hospitalized.After 1 week ,1 month and 3 months of treatment, t he scores in CRP normal group significantly reduced to 12±7,10±6 and 8±5 resp ectively, as compared with those in CRP increased group(14±7,12±7 and 11±7 re spectively)(z=2.037,P=0.042; z=2.319,P=0.020; z=2.681,P=0.007, respectively).
出处
《中国临床康复》
CSCD
2003年第25期3418-3419,共2页
Chinese Journal of Clinical Rehabilitation
关键词
脑缺血
C反应蛋白
预后
散射比浊法
The level of serum CRP in patients following acute ischemic stroke can be used as an important prognostic factor of the disease.
