摘要
AIM:To evaluate the role of mitochondrial microsatellite instability (mtMSI) in gastric carcinogenesis.METHODS:MtMSI was measured with PCR-single strand conformation polymophism (PCR-SSCP) in 68 cases of advanced gastric cancer,40 cases of chronic gastritis,30 cases of intestinal metaplasia and 20 cases of dysplasia.RESULTS:MtMSI was observed in 12.5% (5 of 40) of chronic gastritis,20.0% (6 of 30) of intestinal metaplasia,25.0% (5 of 20) of dysplasia and 38.2% (26 of 68) of gastric cancer.These findings showed a sequential accumulation of mtMSI in the histological progression from chonic gastritis to gastric cancer. An association of mtMSI with intestinal histological type and distal location was found (P=0.001 and P=0.002), whereas no significant correlation was found between mtMSI and age at diagnosis, sex, tumor size, depth of invasion, lymph node spread and clinical stages (P>0.05).CONCLUSION:MtMSI may play an early and important role in the gastric carcinogenesis pathway, especially in the intestinal type and distal gastric cancer.
AIM:To evaluate the role of mitochondrial microsatellite instability (mtMSI) in gastric carcinogenesis. METHODS:MtMSI was measured with PCR-single strand conformation polymophism (PCR-SSCP) in 68 cases of advanced gastric cancer,40 cases of chronic gastritis,30 cases of intestinal metaplasia and 20 cases of dysplasia. RESULTS:MtMSI was observed in 12.5% (5 of 40) of chronic gastritis,20.0% (6 of 30) of intestinal metaplasia, 25.0% (5 of 20) of dysplasia and 38.2% (26 of 68) of gastric cancer.These findings showed a sequential accumulation of mtMSI in the histological progression from chonic gastritis to gastric cancer.An association of mtMSI with intestinal histological type and distal location was found (P=0.001 and P=0.002),whereas no significant correlation was found between mtMSI and age at diagnosis,sex,tumor size,depth of invasion,lymph node spread and clinical stages (P>0.05). CONCLUSION:MtMSI may play an early and important role in the gastric carcinogenesis pathway,especially in the intestinal type and distal gastric cancer.
基金
Supported by the National Natural Science Foundation ot China,No.30070043
Scientific Research Project of Chinese PLA during the 10~(th) Five-year plan period,No.01Z075
