摘要
本文对高血压心脏病34例,以二维及多普勒超声和放射免疫测定法观察卡托普利治疗前后其LVM和血浆AⅡ浓度的变化。证明卡托普利长程治疗可使82.4%(28/34例)的患者的LVM有不同程度的消退,且约半效由LVH逆转为正常。并发现LVM的消退与血浆AⅡ浓度的下降幅度密切相关(r=0.812)。显示卡托普利对高心病LVM的消退作用与其对RAS生成AⅡ的抑制作用有关。
Colour Doppler ultrasonic diagnostic apparatus and radioimmunoassay were used to study the changes of LVM and plasma angiotensin Ⅱ (AII) of 34 patients with hypertensive left ventricular hypertrophy before and after captopril treatment. The results showed that LVM Ⅰ of 28 patients (82.4%) was reduced after treatment with captopril for 6 to 8 months. LVM Ⅰ of 13 of 31patients with left ventricular hypertrophy became normal and plasma AII concentration was reduced from 159.84±57.63pg/ml before treatment to 87.63±13.30pg/ml after treatment. There was positive correlation between AII and LVM Ⅰ(r=0.812). It suggests that captopril can reduce left ventricular myocardial weight of patients with hypertensive myocardial hypertrophy.
出处
《中国循环杂志》
CSCD
1992年第2期141-143,共3页
Chinese Circulation Journal
关键词
卡托普利
血管紧张素
心肌肥厚
Captopril
Angiotensin Ⅱ
Left ventricular hypertrophy
